Atrial Natriuretic Peptide Response Is Blunted in Patients with Acute Myocardial Infarction and Mild Left Ventricular Dysfunction

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Abstract

Neurohumoral parameters in 45 asymptomatic patients with acute myocardial infarction were measured. In patients with mild left ventricular dysfunction (ejection fraction < 45% and/or left ventricular end-diastolic pressure > 15 mm Hg), atrial natriuretic peptide levels differed significantly from those in patients with normal left ventricular function (127 ± 74pg/ml vs. 79 ± 71 pg/ml; p < 0.001). After stimulus an increase in atrial natriuretic peptide levels (79 ± 71 to 118 ± 86 pg/ml; p < 0.001) was found only in patients with normal hemodynamic parameters. These data show that in patients with left ventricular dysfunction, the atrial natriuretic system is activated; however, atrial natriuretic peptide response to stimulus is present only in patients with normal hemodynamics.

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Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1994

Publication date (Print): 1994

Publication date (Electronic): 18 November 2008

Volume: 84

Issue: 2

Pages: 79-88

Affiliations

^aCardiology Division and ^bNuclear Medicine Service, EO Ospedali Galliera, Genova, Italy

Article

Publisher ID: 176525 Other ID: Cardiology 1994;84:79–88

DOI: 10.1159/000176525

PubMed ID: 8174145

SO-VID: 30af6f60-0645-4871-abdc-91086f4d0fe9

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 12 October 1993

Date accepted : 15 October 1993

Page count

Pages: 10

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