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      Total sulfur amino acid requirement in young men as determined by indicator amino acid oxidation with l-[1-13C]phenylalanine

      1 , 1 , 1 , 1
      The American Journal of Clinical Nutrition
      Oxford University Press (OUP)

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          Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats.

          The plasma homocysteine response to methionine loading was assessed in vitamin B-6- and folate-deficient rats. Rats fed vitamin B-6- or folate-deficient diets for 4 wk were administered a gastric gavage of methionine (100 mg/kg body wt). Subsequent plasma analyses revealed a peak post-methionine load increase in plasma homocysteine concentration of > 300 mumol/L in the vitamin B-6-deficient rats. Folate-deficient rats exhibited no significant changes in plasma homocysteine after the load. These disparate responses can be explained by the observed increase in hepatic S-adenosylmethionine (SAM) concentration because of the load. In vitamin B-6 deficiency, increased SAM inhibits homocysteine remethylation, which, in conjunction with the impaired homocysteine catabolism due to the deficiency and the increased synthesis of homocysteine due to the methionine load, leads to a large elevation of homocysteine in the blood. In folate deficiency, increased SAM activates homocysteine catabolism, which compensates for the increased synthesis of homocysteine due to the load and thus no change in blood homocysteine is observed. These results have significant bearing on the interpretation of both positive and negative responses to methionine loading in humans.
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            Human amino acid requirements: can the controversy be resolved?

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              The design and validation of a diet for studies of amino acid metabolism in adult humans

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                Author and article information

                Journal
                The American Journal of Clinical Nutrition
                Oxford University Press (OUP)
                0002-9165
                1938-3207
                December 2001
                December 01 2001
                December 2001
                December 01 2001
                : 74
                : 6
                : 756-760
                Affiliations
                [1 ] From the Departments of Nutritional Sciences and Paediatrics, the University of Toronto; The Research Institute, The Hospital for Sick Children, Toronto; the School of Dietetics & Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Canada; and the Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada.
                Article
                10.1093/ajcn/74.6.756
                11722956
                30b5e8aa-b6cb-479b-b219-eb2d961b7711
                © 2001
                History

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