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      Accessing genetic variation: genotyping single nucleotide polymorphisms.

      Nature reviews. Genetics
      Alleles, Animals, Genetic Variation, Genotype, Humans, Nucleic Acid Hybridization, Polymerase Chain Reaction, Polymorphism, Single Nucleotide

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          Abstract

          Understanding the relationship between genetic variation and biological function on a genomic scale is expected to provide fundamental new insights into the biology, evolution and pathophysiology of humans and other species. The hope that single nucleotide polymorphisms (SNPs) will allow genes that underlie complex disease to be identified, together with progress in identifying large sets of SNPs, are the driving forces behind intense efforts to establish the technology for large-scale analysis of SNPs. New genotyping methods that are high throughput, accurate and cheap are urgently needed for gaining full access to the abundant genetic variation of organisms.

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          Author and article information

          Journal
          11733746
          10.1038/35103535

          Chemistry
          Alleles,Animals,Genetic Variation,Genotype,Humans,Nucleic Acid Hybridization,Polymerase Chain Reaction,Polymorphism, Single Nucleotide

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