<div class="section">
<a class="named-anchor" id="ab-noi170078-1">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d1752723e282">Importance</h5>
<p id="d1752723e284">Despite the introduction of combination antiretroviral therapy
(cART), HIV-associated
neurocognitive disorders continue to be a problem for treated HIV-positive individuals.
The cause of this impairment remains unclear.
</p>
</div><div class="section">
<a class="named-anchor" id="ab-noi170078-2">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d1752723e287">Objective</h5>
<p id="d1752723e289">To determine if detectable brain changes occur during a 2-year
period in HIV-positive
individuals who were aviremic and treated with cART.
</p>
</div><div class="section">
<a class="named-anchor" id="ab-noi170078-3">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d1752723e292">Design, Setting, and Participants</h5>
<p id="d1752723e294">In this longitudinal case-control study, participants underwent
neuroimaging and neuropsychological
assessment approximately 2 years apart. Data were collected from October 26, 2011,
to March 1, 2016. Data from 92 HIV-positive individuals were acquired at Washington
University in St Louis from ongoing studies conducted in the infectious disease clinic
and AIDS Clinical Trial Unit. A total of 55 HIV-negative control participants were
recruited from the St Louis community and a research participant registry. A total
of 48 HIV-positive individuals who were aviremic and treated with cART and 31 demographically
similar HIV-negative controls met the study requirements and were included in the
analyses.
</p>
</div><div class="section">
<a class="named-anchor" id="ab-noi170078-4">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d1752723e297">Main Outcomes and Measures</h5>
<p id="d1752723e299">Brain volumes were extracted with tensor-based and voxel-based
morphometry and cortical
modeling. Raw scores from neuropsychological tests quantified cognitive performance.
Multivariable mixed-effects models assessed the effect of HIV serostatus on brain
volumes and cognitive performance, and determined if HIV serostatus affected how these
measures changed over time. With HIV-positive participants, linear regression models
tested whether brain volumes and cognitive performance were associated with measures
of infection severity and duration of infection.
</p>
</div><div class="section">
<a class="named-anchor" id="ab-noi170078-5">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d1752723e302">Results</h5>
<p id="d1752723e304">The 2 groups were demographically similar (HIV-positive group:
23 women and 25 men;
mean [SD] age, 47.7 [13.2] years; mean [SD] educational level, 13.3 [3.4] years; and
HIV-negative group, 16 women and 15 men; mean [SD] age, 51.2 [12.9] years; mean [SD]
educational level, 14.5 [2.1] years). The HIV-positive participants had poorer neuropsychological
test scores compared with controls on the Trail Making Test Part A (5.9 seconds; 95%
CI, 1.5-10.3;
<i>P</i> = .01), Trail Making Test Part B (27.3 seconds; 95% CI, 15.0-39.6;
<i>P</i> < .001), Digit Symbol Substitution Task (–12.5 marks; 95% CI, –18.9 to
–6.0;
<i>P</i> < .001), Letter-Number Sequencing (–2.5 marks; 95% CI, –3.7 to –1.3;
<i>P</i> < .001), Letter Fluency (–6.6 words; 95% CI, –11.5 to –1.6;
<i>P</i> = .01), and Hopkins Verbal Learning Test–Revised immediate recall (–2.4 words;
95%
CI, –4.4 to –0.4;
<i>P</i> = .05), after adjusting for age, sex, and educational level. Only changes
in Trail
Making Test Part A significantly differed between the groups. Cortical thickness and
subcortical volumes were smaller in HIV-positive individuals compared with controls.
However, changes in brain volume over time were similar between the groups.
</p>
</div><div class="section">
<a class="named-anchor" id="ab-noi170078-6">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d1752723e326">Conclusions and Relevance</h5>
<p id="d1752723e328">These findings are consistent with the idea that cognitive and
structural brain changes
may occur early after seroconversion, and argue that maintaining aviremia with cART
can prevent or minimize progressive brain injury.
</p>
</div><p class="first" id="d1752723e331">This longitudinal case-control study examines
whether detectable brain changes occur
during a 2-year period in HIV-positive individuals who were aviremic and treated with
combination antiretroviral therapy.
</p><div class="section">
<a class="named-anchor" id="ab-noi170078-7">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d1752723e337">Question</h5>
<p id="d1752723e339">Do HIV-positive individuals receiving combination antiretroviral
therapy with good
viral suppression experience progressive brain atrophy and cognitive decline?
</p>
</div><div class="section">
<a class="named-anchor" id="ab-noi170078-8">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d1752723e342">Findings</h5>
<p id="d1752723e344">In this longitudinal case-control study that included 48 HIV-positive
individuals
who were aviremic and treated with combination antiretroviral therapy and 31 demographically
similar controls, HIV-positive participants had reduced cortical thickness and subcortical
brain volumes and poorer cognitive performance compared with controls. However, the
changes in cognitive performance and brain volumes during a 2-year period were similar
between the groups.
</p>
</div><div class="section">
<a class="named-anchor" id="ab-noi170078-9">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d1752723e347">Meaning</h5>
<p id="d1752723e349">Infection with HIV may result in reduced brain volumes and decreased
cognitive performance,
but early initiation of treatment and maintaining full viral suppression may minimize
brain injury in HIV-positive individuals.
</p>
</div>