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      Tumour biology: senescence in premalignant tumours.

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          Abstract

          Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          1476-4687
          0028-0836
          Aug 04 2005
          : 436
          : 7051
          Affiliations
          [1 ] Spanish National Cancer Centre (CNIO), Madrid 28029, Spain.
          Article
          436642a
          10.1038/436642a
          16079833
          30cd2b56-4033-47ee-95fe-e31a2a215cc3
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