Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.

Nature immunology

Animals, Cell Line, Tumor, Cells, Cultured, DNA-Binding Proteins, metabolism, Gene Expression Regulation, Genes, Reporter, genetics, Humans, Interferon Regulatory Factor-3, Interferons, biosynthesis, immunology, Mice, NF-kappa B, Promoter Regions, Genetic, Protein Structure, Tertiary, Proteins, chemistry, RNA Helicases, RNA, Double-Stranded, physiology, RNA, Messenger, RNA, Small Interfering, Sequence Deletion, Signal Transduction, Transcription Factors, Transcriptional Activation, Viruses, growth & development

Read this article at

ScienceOpenPublisherPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Intracellular double-stranded RNA (dsRNA) is a chief sign of replication for many viruses. Host mechanisms detect the dsRNA and initiate antiviral responses. In this report, we identify retinoic acid inducible gene I (RIG-I), which encodes a DExD/H box RNA helicase that contains a caspase recruitment domain, as an essential regulator for dsRNA-induced signaling, as assessed by functional screening and assays. A helicase domain with intact ATPase activity was responsible for the dsRNA-mediated signaling. The caspase recruitment domain transmitted 'downstream' signals, resulting in the activation of transcription factors NF-kappaB and IRF-3. Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes.

      Related collections

      Author and article information

      Journal
      15208624
      10.1038/ni1087

      Comments

      Comment on this article