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      EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

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          Abstract

          Although mutant H3K27M histones inhibit PRC2 in diffuse intrinsic pontine gliomas, these tumors exhibit significant amounts of PRC2 activity. The repression of several genes, including INK4A, by residual EZH2 activity is required for tumor growth, and EZH2 inhibitors therefore represent potential therapies for these patients.

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          Author and article information

          Journal
          Nature Medicine
          Nat Med
          Springer Nature
          1078-8956
          1546-170X
          February 27 2017
          February 27 2017
          :
          :
          Article
          10.1038/nm.4293
          28263309
          30f2edef-f874-42f4-8280-8344e304ea65
          © 2017
          History

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