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      Epidemiological trends in 1,452 cases of retinoblastoma from the Surveillance, Epidemiology, and End Results (SEER) registry

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          Abstract

          Purpose

          To assess retinoblastoma epidemiological trends in the Surveillance, Epidemiology, and End Results (SEER) registry.

          Methods

          All cases of retinoblastoma in the SEER database from 1973–2009 were identified. Kaplan-Meier survival analyses were performed for pathological grade, patient age, gender, year of diagnosis, and treatment modality. Cox proportional hazards regression assessed the impact of patient and tumor characteristics on survival.

          Findings

          1,452 cases of retinoblastoma were analyzed. The mean patient age at diagnosis was 1.44 years. The tumor was unilateral in 71.0% or bilateral in 29.0%. The mean follow-up was 129.1 months. Overall survival increased during the study interval. Patients with bilateral tumors were diagnosed at an earlier age (0.46 years) than patients with unilateral disease (1.77 years; P < 0.0001). Bilateral retinoblastoma (90.3% 10-year overall survival) was associated with decreased overall survival than unilateral retinoblastoma (96.1% 10-year overall survival). Bilateral retinoblastoma was also associated with an increased incidence of non-ocular malignancies (7.8%) compared with unilateral retinoblastoma (1.3%; P < 0.0001). Grade 1 tumors were diagnosed at a younger age (0.94 years) than grade 3 (2.24 years) and grade 4 tumors (2.14 years; P < 0.0001). Lower grade and lower stage tumors were independently associated with increased survival. In multivariate Cox proportional hazards analysis, T stage and laterality were the only covariates that correlated with overall survival.

          Conclusions

          There appear to be associations between retinoblastoma tumor features such as tumor stage, pathological grade, and laterality with patient characteristics such as age at diagnosis, overall survival, and second malignancies.

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          Author and article information

          Journal
          0045312
          2740
          Can J Ophthalmol
          Can. J. Ophthalmol.
          Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
          0008-4182
          1715-3360
          10 August 2017
          22 July 2017
          December 2017
          01 December 2018
          : 52
          : 6
          : 592-598
          Affiliations
          [1 ]Illinois Eye and Ear Infirmary, UIC Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL, USA
          Author notes
          Corresponding Author: Michael Andreoli, M.D., Department of Ophthalmology and Visual Sciences, 1855 W. Taylor St., Chicago, IL 60612, michaelandreoli@ 123456gmail.com , 312-996-6660
          Article
          PMC5726447 PMC5726447 5726447 nihpa894856
          10.1016/j.jcjo.2017.05.012
          5726447
          29217028
          30fbc4af-ea1e-4df4-b85c-95582fc8f1b9
          History
          Categories
          Article

          epidemiology,ocular oncology,Retinoblastoma,Retina
          epidemiology, ocular oncology, Retinoblastoma, Retina

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