4
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Continuous-time stochastic processes for the spread of COVID-19 disease simulated via a Monte Carlo approach and comparison with deterministic models

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Two stochastic models are proposed to describe the evolution of the COVID-19 pandemic. In the first model the population is partitioned into four compartments: susceptible S, infected I, removed R and dead people D. In order to have a cross validation, a deterministic version of such a model is also devised which is represented by a system of ordinary differential equations with delays. In the second stochastic model two further compartments are added: the class A of asymptomatic individuals and the class L of isolated infected people. Effects such as social distancing measures are easily included and the consequences are analyzed. Numerical solutions are obtained with Monte Carlo simulations. Quantitative predictions are provided which can be useful for the evaluation of political measures, e.g. the obtained results suggest that strategies based on herd immunity are too risky. Finally, the models are calibrated on data referring to the second wave of infection in Italy.

          Related collections

          Most cited references18

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          A pneumonia outbreak associated with a new coronavirus of probable bat origin

          Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats 1–4 . Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans 5–7 . Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            A Contribution to the Mathematical Theory of Epidemics

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Prevalence of Asymptomatic SARS-CoV-2 Infection

              Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly throughout the world since the first cases of coronavirus disease 2019 (COVID-19) were observed in December 2019 in Wuhan, China. It has been suspected that infected persons who remain asymptomatic play a significant role in the ongoing pandemic, but their relative number and effect have been uncertain. The authors sought to review and synthesize the available evidence on asymptomatic SARS-CoV-2 infection. Asymptomatic persons seem to account for approximately 40% to 45% of SARS-CoV-2 infections, and they can transmit the virus to others for an extended period, perhaps longer than 14 days. Asymptomatic infection may be associated with subclinical lung abnormalities, as detected by computed tomography. Because of the high risk for silent spread by asymptomatic persons, it is imperative that testing programs include those without symptoms. To supplement conventional diagnostic testing, which is constrained by capacity, cost, and its one-off nature, innovative tactics for public health surveillance, such as crowdsourcing digital wearable data and monitoring sewage sludge, might be helpful.
                Bookmark

                Author and article information

                Contributors
                fabianacalleri@yahoo.it
                g.nastasi@unict.it
                romano@dmi.unict.it
                Journal
                J Math Biol
                J Math Biol
                Journal of Mathematical Biology
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                0303-6812
                1432-1416
                14 September 2021
                14 September 2021
                2021
                : 83
                : 4
                : 34
                Affiliations
                GRID grid.8158.4, ISNI 0000 0004 1757 1969, Dipartimento di Matematica e Informatica, , Università degli Studi di Catania, ; Viale Andrea Doria 6, 95125 Catania, Italy
                Author information
                http://orcid.org/0000-0002-2967-6552
                Article
                1657
                10.1007/s00285-021-01657-4
                8439375
                34129100
                30ff4c69-edfa-47c1-87bf-253e5da34e47
                © The Author(s) 2021

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 16 March 2021
                : 15 June 2021
                : 29 August 2021
                Funding
                Funded by: INdAM (GNFM)
                Categories
                Article
                Custom metadata
                © Springer-Verlag GmbH Germany, part of Springer Nature 2021

                Quantitative & Systems biology
                covid-19,stochastic process,epidemic model,monte carlo simulation,92d30,65c35

                Comments

                Comment on this article