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      Overview of preparation methods of polymeric and lipid-based (niosome, solid lipid, liposome) nanoparticles: A comprehensive review

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          Liposomes as nanomedical devices

          Since their discovery in the 1960s, liposomes have been studied in depth, and they continue to constitute a field of intense research. Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier system known to date. Notable progress has been made, and several biomedical applications of liposomes are either in clinical trials, are about to be put on the market, or have already been approved for public use. In this review, we briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization. Moreover, we discuss the influence of the physicochemical properties of liposomes on their interaction with cells, half-life, ability to enter tissues, and final fate in vivo. Finally, we describe some strategies developed to overcome limitations of the “first-generation” liposomes, and liposome-based drugs on the market and in clinical trials.
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            Liposomes in drug delivery: Progress and limitations

            A N Sharma (1997)
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              Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications.

              The poor oral bioavailability arising from poor aqueous solubility should make drug research and development more difficult. Various approaches have been developed with a focus on enhancement of the solubility, dissolution rate, and oral bioavailability of poorly water-soluble drugs. To complete development works within a limited amount of time, the establishment of a suitable formulation strategy should be a key consideration for the pharmaceutical development of poorly water-soluble drugs. In this article, viable formulation options are reviewed on the basis of the biopharmaceutics classification system of drug substances. The article describes the basic approaches for poorly water-soluble drugs, such as crystal modification, micronization, amorphization, self-emulsification, cyclodextrin complexation, and pH modification. Literature-based examples of the formulation options for poorly water-soluble compounds and their practical application to marketed products are also provided. Classification of drug candidates based on their biopharmaceutical properties can provide an indication of the difficulty of drug development works. A better understanding of the physicochemical and biopharmaceutical properties of drug substances and the limitations of each delivery option should lead to efficient formulation development for poorly water-soluble drugs. Copyright © 2011 Elsevier B.V. All rights reserved.
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                Author and article information

                Journal
                International Journal of Polymeric Materials and Polymeric Biomaterials
                International Journal of Polymeric Materials and Polymeric Biomaterials
                Informa UK Limited
                0091-4037
                1563-535X
                December 21 2017
                April 13 2018
                August 28 2017
                April 13 2018
                : 67
                : 6
                : 383-400
                Affiliations
                [1 ] Department of Nano Biotechnology, Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran, Iran
                [2 ] Department of Biotechnology and Pharmaceutical Engineering, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
                [3 ] Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran
                [4 ] Department of Oral & Maxillofacial Surgery, VU University Medical Center, MOVE Research Institute Amsterdam
                [5 ] Department of Biotechnology, Faculty of Advanced Science and Technologies, University of Isfahan, Isfahan, Iran
                Article
                10.1080/00914037.2017.1332623
                3104d345-722b-4f80-aa73-824fee836643
                © 2018
                History

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