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Abstract
<p class="first" id="P3">The development of new heterologous hosts for polyketides
production represents an
excellent opportunity to expand the genomic, physiological, and biochemical backgrounds
that better fit the sustainable production of these valuable molecules. Cyanobacteria
are particularly attractive for the production of natural compounds because they have
minimal nutritional demands and several strains have well established genetic tools.
Using the model strain
<i>Synechococcus elongatus</i>, a generic platform was developed for the heterologous
production of polyketide synthase
(PKS)-derived compounds. The versatility of this system is based on interchangeable
modules harboring promiscuous enzymes for PKS activation and the production of PKS
extender units, as well as inducible circuits for a regulated expression of the PKS
biosynthetic gene cluster. To assess the capability of this platform, we expressed
the mycobacterial PKS-based mycocerosic biosynthetic pathway to produce multimethyl-branched
esters (MBE). This work is a foundational step forward for the production of high
value polyketides in a photosynthetic microorganism.
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