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      Secondary interactions involving zinc-bound ligands: Roles in structural stabilization and macromolecular interactions

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      Journal of Inorganic Biochemistry
      Elsevier BV

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          Abstract

          A large number of proteins contain bound zinc ions. These zinc ions are frequently coordinated by a combination of histidine and cysteine residues. In addition to atoms that coordinate directly to the zinc ions, these side chains have groups that can donate or accept hydrogen bonds from other groups. These secondary interactions can help stabilize the zinc-binding sites, can contribute to protein folding and stability, and, on occasion, can participate in interactions with other macromolecules. Five examples of these secondary interactions are discussed: carbonic anhydrase (where secondary interactions involving histidine residues stabilize the zinc-binding site thermodynamically and kinetically), retroviral nucleocapsid proteins and TRAF proteins (where cysteinate sulfur to peptide NH hydrogen bonds contribute to the structural relationships between adjacent domains), and nucleic acid binding proteins, Zif268 and TIS11 where secondary interactions participate in protein-nucleic acid interactions.

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          Author and article information

          Journal
          Journal of Inorganic Biochemistry
          Journal of Inorganic Biochemistry
          Elsevier BV
          01620134
          June 2012
          June 2012
          : 111
          : 146-149
          Article
          10.1016/j.jinorgbio.2011.10.018
          3371127
          22196020
          31214b41-950f-4d34-8406-72e420f8d036
          © 2012

          https://www.elsevier.com/tdm/userlicense/1.0/

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