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      Intravenous zoledronic acid in postmenopausal women with low bone mineral density.

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          Abstract

          Bisphosphonates are effective agents for the management of osteoporosis. Their low bioavailability and low potency necessitate frequent administration on an empty stomach, which may reduce compliance. Gastrointestinal intolerance limits maximal dosing. Although intermittent intravenous treatments have been used, the optimal doses and dosing interval have not been systematically explored.

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          Author and article information

          Journal
          N Engl J Med
          The New England journal of medicine
          Massachusetts Medical Society
          1533-4406
          0028-4793
          Feb 28 2002
          : 346
          : 9
          Affiliations
          [1 ] Department of Medicine, University of Auckland, Auckland, New Zealand. i.reid@auckland.ac.nz
          Article
          346/9/653
          10.1056/NEJMoa011807
          11870242
          31261840-9374-46ca-83d6-816d6d3db73d
          History

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