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      Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

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          Abstract

          Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural‐based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as Solanum nigrum and Claviceps purpurea and isolated herbal compounds (e.g., curcumin, resveratrol, and matairesinol) combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions. Plant products are not free of risks: Herb adverse effects, including herb–drug interactions, should be carefully considered.

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          This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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          Doxorubicin Cardiomyopathy

          Kanu Chatterjee, Jianqing Zhang, Norman Honbo … (2010)
          Established doxorubicin cardiomyopathy is a lethal disease. When congestive heart failure develops, mortality is approximately 50%. Extensive research has been done to understand the mechanism and pathophysiology of doxorubicin cardiomyopathy, and considerable knowledge and experience has been gained. Unfortunately, no effective treatment for established doxorubicin cardiomyopathy is presently available. Extensive research has been done and is being done to discover preventive treatments. However an effective and clinically applicable preventive treatment is yet to be discovered.
          Article 0 comments Cited 316 times – based on 0 reviews     Review now
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            Is Open Access

            Natural Antioxidants in Foods and Medicinal Plants: Extraction, Assessment and Resources

            Dong-Ping Xu, Ya Ying Li, Xiao-xiao Meng … (2017)
            Natural antioxidants are widely distributed in food and medicinal plants. These natural antioxidants, especially polyphenols and carotenoids, exhibit a wide range of biological effects, including anti-inflammatory, anti-aging, anti-atherosclerosis and anticancer. The effective extraction and proper assessment of antioxidants from food and medicinal plants are crucial to explore the potential antioxidant sources and promote the application in functional foods, pharmaceuticals and food additives. The present paper provides comprehensive information on the green extraction technologies of natural antioxidants, assessment of antioxidant activity at chemical and cellular based levels and their main resources from food and medicinal plants.
            Article 0 comments Cited 262 times – based on 0 reviews     Review now
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              Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies.

              Wen-Wen Li, Han Zhang, Yehuda G. Assaraf … (2016)
              Multidrug resistance is a key determinant of cancer chemotherapy failure. One of the major causes of multidrug resistance is the enhanced efflux of drugs by membrane ABC transporters. Targeting ABC transporters projects a promising approach to eliminating or suppressing drug resistance in cancer treatment. To reveal the functional mechanisms of ABC transporters in drug resistance, extensive studies have been conducted from identifying drug binding sites to elucidating structural dynamics. In this review article, we examined the recent crystal structures of ABC proteins to depict the functionally important structural elements, such as domains, conserved motifs, and critical amino acids that are involved in ATP-binding and drug efflux. We inspected the drug-binding sites on ABC proteins and the molecular mechanisms of various substrate interactions with the drug binding pocket. While our continuous battle against drug resistance is far from over, new approaches and technologies have emerged to push forward our frontier. Most recent developments in anti-MDR strategies include P-gp inhibitors, RNA-interference, nano-medicines, and delivering combination strategies. With the advent of the 'Omics' era - genomics, epigenomics, transcriptomics, proteomics, and metabolomics - these disciplines play an important role in fighting the battle against chemoresistance by further unraveling the molecular mechanisms of drug resistance and shed light on medical therapies that specifically target MDR.
              Article 0 comments Cited 233 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Ching‐Feng Weng:
                ORCID: https://orcid.org/0000-0002-9747-8697
                cfweng-cfweng@hotmail.com
                Journal
                Journal ID (nlm-ta): Br J Pharmacol
                Journal ID (iso-abbrev): Br. J. Pharmacol
                Journal ID (doi): 10.1111/(ISSN)1476-5381
                Journal ID (publisher-id): BPH
                Title: British Journal of Pharmacology
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Print): 0007-1188
                ISSN (Electronic): 1476-5381
                Publication date (Electronic): 27 November 2019
                Publication date (Print): March 2020
                Publication date PMC-release: 27 November 2019
                Volume: 177
                Issue: 6 , Themed Issue: The Pharmacology of Nutraceuticals. Guest Editors: Ruth Andrew and Angelo A. Izzo ( doiID: 10.1111/bph.v177.6 )
                Pages: 1409-1423
                Affiliations
                [ 1 ] Department of Life Science and Institute of Biotechnology National Dong Hwa University Hualien Taiwan
                [ 2 ] Center for Prevention and Therapy of Gynaecological Cancers, Department of Research Tzu Chi Hospital Hualien Taiwan
                [ 3 ] Neural Regeneration Laboratory, Neurological Institute Taipei Veterans General Hospital Taipei City Taiwan
                [ 4 ] Department of Chemistry National Dong Hwa University Hualien Taiwan
                [ 5 ] Graduate Institute of Marine Biotechnology National Dong Hwa University Pingtung Taiwan
                [ 6 ] Department of Biotechnology Southern Taiwan University of Science and Technology Tainan City Taiwan
                [ 7 ] Department of Basic Medical Science, Center for Transitional Medicine Xiamen Medical College Xiamen China
                Author notes
                [*] [* ] Correspondence

                Ching‐Feng Weng, Department of Basic Medical Science, Center for Transitional Medicine, Xiamen Medical College, Xiamen 361023, China.

                Email: cfweng-cfweng@ 123456hotmail.com

                Author information
                https://orcid.org/0000-0002-4160-2361
                https://orcid.org/0000-0002-9747-8697
                Article
                Publisher ID: BPH14816 Other ID: 2019-BJP-0451-R.R3
                DOI: 10.1111/bph.14816
                PMC ID: 7056458
                PubMed ID: 31368509
                SO-VID: 313a18d9-438c-4737-ac38-184cc58cc7f2
                Copyright © © 2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 20 April 2019
                Date revision received : 19 July 2019
                Date accepted : 26 July 2019
                Page count
                Figures: 2, Tables: 3, Pages: 15, Words: 10749
                Categories
                Subject: Review Article
                Subject: Themed Section: Review Articles
                Custom metadata
                source-schema-version-number 2.0
                cover-date March 2020
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.7.7 mode:remove_FC converted:04.03.2020

                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Data availability:
                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine

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