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      Haemolysis in Chronic Renal Failure

      Nephron

      S. Karger AG

      Chronic renal failure, Anaemia, Haemolysis, Methionine

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          Abstract

          In a group of patients with a range of degree of advancement of renal failure, the red cell survival estimated as the half-life of radiochromium-labelled red blood cells (T<sub>½</sub>.<sup>51</sup>Cr) was correlated with several indices of renal failure. The T<sub>½</sub>. <sup>51</sup>Cr was not improved by a dialysis programme which was otherwise adequate. Furthermore, the correlation of a T<sub>½</sub>. <sup>51</sup>Cr to the biochemical indices of renal failure was lost which might suggest that some other factor or factors than those measured was the ultimate correlate with red cell survival. This work adds to the circumstantial evidence in favour of a guanidine or a similarly behaving molecule being the haemolyzing agent. The additional premise is extended that a methionine-rich diet will inhibit the haemolytic factor.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 32
          : 1
          : 28-31
          Affiliations
          Nephrologist, Senior Lecturer in Medicine, University of Otago, Dunedin, New Zealand
          Article
          182727 Nephron 1982;32:28–31
          10.1159/000182727
          7177274
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Methionine, Haemolysis, Anaemia, Chronic renal failure

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