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      The Third Annual Meeting of the European Virus Bioinformatics Center

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          Abstract

          The Third Annual Meeting of the European Virus Bioinformatics Center (EVBC) took place in Glasgow, United Kingdom, 28–29 March 2019. Virus bioinformatics has become central to virology research, and advances in bioinformatics have led to improved approaches to investigate viral infections and outbreaks, being successfully used to detect, control, and treat infections of humans and animals. This active field of research has attracted approximately 110 experts in virology and bioinformatics/computational biology from Europe and other parts of the world to attend the two-day meeting in Glasgow to increase scientific exchange between laboratory- and computer-based researchers. The meeting was held at the McIntyre Building of the University of Glasgow; a perfect location, as it was originally built to be a place for “rubbing your brains with those of other people”, as Rector Stanley Baldwin described it. The goal of the meeting was to provide a meaningful and interactive scientific environment to promote discussion and collaboration and to inspire and suggest new research directions and questions. The meeting featured eight invited and twelve contributed talks, on the four main topics: (1) systems virology, (2) virus-host interactions and the virome, (3) virus classification and evolution and (4) epidemiology, surveillance and evolution. Further, the meeting featured 34 oral poster presentations, all of which focused on specific areas of virus bioinformatics. This report summarizes the main research findings and highlights presented at the meeting.

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          Most cited references38

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          Epidemiology of severe sepsis

          Severe sepsis is a leading cause of death in the United States and the most common cause of death among critically ill patients in non-coronary intensive care units (ICU). Respiratory tract infections, particularly pneumonia, are the most common site of infection, and associated with the highest mortality. The type of organism causing severe sepsis is an important determinant of outcome, and gram-positive organisms as a cause of sepsis have increased in frequency over time and are now more common than gram-negative infections. Recent studies suggest that acute infections worsen pre-existing chronic diseases or result in new chronic diseases, leading to poor long-term outcomes in acute illness survivors. People of older age, male gender, black race, and preexisting chronic health conditions are particularly prone to develop severe sepsis; hence prevention strategies should be targeted at these vulnerable populations in future studies.
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            Role for migratory wild birds in the global spread of avian influenza H5N8.

            (2016)
            Avian influenza viruses affect both poultry production and public health. A subtype H5N8 (clade 2.3.4.4) virus, following an outbreak in poultry in South Korea in January 2014, rapidly spread worldwide in 2014-2015. Our analysis of H5N8 viral sequences, epidemiological investigations, waterfowl migration, and poultry trade showed that long-distance migratory birds can play a major role in the global spread of avian influenza viruses. Further, we found that the hemagglutinin of clade 2.3.4.4 virus was remarkably promiscuous, creating reassortants with multiple neuraminidase subtypes. Improving our understanding of the circumpolar circulation of avian influenza viruses in migratory waterfowl will help to provide early warning of threats from avian influenza to poultry, and potentially human, health.
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              Evolutionary relationships among diverse bacteriophages and prophages: All the world's a phage

                Author and article information

                Journal
                Viruses
                Viruses
                viruses
                Viruses
                MDPI
                1999-4915
                05 May 2019
                May 2019
                : 11
                : 5
                : 420
                Affiliations
                [1 ]European Virus Bioinformatics Center, 07743 Jena, Germany; bashar.ibrahim@ 123456uni-jena.de (B.I.); Stefanie.Deinhardt-Emmer@ 123456med.uni-jena.de (S.D.-E.); bedutilh@ 123456gmail.com (B.E.D.); volker.thiel@ 123456vetsuisse.unibe.ch (V.T.); Evelien.Adriaenssens@ 123456quadram.ac.uk (E.M.A.); kevin.lamkiewicz@ 123456uni-jena.de (K.L.); David.L.Robertson@ 123456glasgow.ac.uk (D.L.R.)
                [2 ]RNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University Jena, 07743 Jena, Germany
                [3 ]Chair of Bioinformatics, Matthias-Schleiden-Institute, Friedrich Schiller University Jena, 07743 Jena, Germany
                [4 ]MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK; s.modha.1@ 123456research.gla.ac.uk
                [5 ]Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK; mrjc1@ 123456leicester.ac.uk
                [6 ]Institute of Medical Microbiology, Jena University Hospital, Am Klinikum 1, D-07747 Jena, Germany
                [7 ]Section for Experimental Virology, Jena University Hospital, Hans-Knöll-Straße 2, D-07745 Jena, Germany
                [8 ]Center for Sepsis Control and Care, Jena University Hospital, D-07747 Jena, Germany
                [9 ]Theoretical Biology and Bioinformatics, Science4Life, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands
                [10 ]Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Geert Grooteplein 26, Nijmegen 6525 GA, The Netherlands
                [11 ]Infection & Immunity Division, Roslin Institute, University of Edinburgh, Midlothian EH25 9RG, UK; samantha.lycett@ 123456ed.ac.uk
                [12 ]Nuffield Department of Medicine, University of Oxford, Peter Medawar Building, South Parks Road, Oxford OX1 3SY, UK; peter.simmonds@ 123456ndm.ox.ac.uk
                [13 ]Institute of Virology and Immunology, 3012 Bern, Switzerland; jenna.kelly@ 123456vetsuisse.unibe.ch
                [14 ]Department of Infectious Diseases and Pathobiology, Vetsuisse Facility, University of Bern, 3012 Bern, Switzerland
                [15 ]University of Tartu, Institute of Technology, 50411 Tartu, Estonia; aare.abroi@ 123456ut.ee
                [16 ]Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK
                [17 ]Department of Zoology, University of Oxford, Parks Rd, Oxford OX1 3PS, UK; marina.escalerazamudio@ 123456zoo.ox.ac.uk
                [18 ]Usher Institute of Population Health Sciences & Informatics, Ashworth Laboratories, Kings Buildings, University of Edinburgh, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK; lu.lu@ 123456ed.ac.uk
                [19 ]Institute of Clinical Molecular Biology, Kiel University, 24118 Kiel, Germany; jsusat@ 123456ikmb.uni-kiel.de
                [20 ]Natural History Museum of Denmark, University of Copenhagen, DK-1123 Copenhagen, Denmark; thomassp@ 123456snm.ku.dk
                Author notes
                [* ]Correspondence: franziska.hufsky@ 123456uni-jena.de (F.H.); manja@ 123456uni-jena.de (M.M.); Tel.: +49-3641-9-46482 (M.M.)
                [†]

                These authors organized the conference.

                Author information
                https://orcid.org/0000-0001-7773-0122
                https://orcid.org/0000-0002-7964-4700
                https://orcid.org/0000-0002-5783-0887
                https://orcid.org/0000-0003-4826-5406
                https://orcid.org/0000-0002-6375-6441
                Article
                viruses-11-00420
                10.3390/v11050420
                6563321
                31060321
                3163229b-1630-48ca-aa74-8feccebdd978
                © 2019 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 28 April 2019
                : 29 April 2019
                Categories
                Article

                Microbiology & Virology
                virology,virus bioinformatics,software,systems virology,metagenomics,virome,viral taxonomy,virus classification,genome evolution,bacteriophage,virosphere

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