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      Simvastatin enhanced antimicrobial effect of Ag+ against E. faecalis infection of dentine through PLGA co-delivery submicron particles.

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          Abstract

          Enterococcus faecalis (E. faecalis) is one of the dominant bacteria for refractory infections of teeth. Silver ions (Ag+) have been proved to be a strong bactericide but with high cytotoxicity and discoloration property. Simvastatin is an agent used for dyslipidemia treatment and has anti-inflammatory property. In this study, Ag+ and simvastatin were for the first time used in combination, and poly (lactide-co-glycolide) (PLGA) submicron particles carrying both Ag+ and simvastatin (AgS-PLGA) were fabricated for further investigations. Results confirmed the enhanced antibacterial activity against E. faecalis of Ag+ by simvastatin. AgS-PLGA could release both Ag+ and simvastatin for 24 days and also showed enhanced antibacterial activities. On dentin slices, AgS-PLGA could enter dentinal tubules by ultrasonic activation and inhibit the colonization of E. faecalis. AgS-PLGA showed no cytotoxicity on MC3T3-E1 cells and slight suppressive effect on RAW-264.7 cells, and could reduce the secretion of IL-6 and IL-1β of RAW-264.7 cells. AgS-PLGA could be developed as a new biomaterial for infection and inflammation control for dental and related medical treatments.

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          Author and article information

          Journal
          J Biomater Sci Polym Ed
          Journal of biomaterials science. Polymer edition
          Informa UK Limited
          1568-5624
          0920-5063
          December 2020
          : 31
          : 18
          Affiliations
          [1 ] The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.
          Article
          10.1080/09205063.2020.1811188
          32880530
          31658cd5-1269-4aa0-9004-1e9c1593d416
          History

          E. faecalis ,PLGA,Simvastatin,antibacterial agent,silver
          E. faecalis , PLGA, Simvastatin, antibacterial agent, silver

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