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      Long-Term Risk of Stroke in Myocardial Infarction Survivors : Thirty-Year Population-Based Cohort Study

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          Abstract

          Improved survival after myocardial infarction (MI) has increased the number of patients at risk of post-MI stroke. We examined risks of ischemic stroke, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in patients with MI compared with the general population.

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          Most cited references19

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          Epidemiology. When an entire country is a cohort.

          L. Frank (2000)
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            Validity of Stroke Diagnoses in a National Register of Patients

            Background: Many registers containing routine medical information have been developed for research and surveillance purposes. In epidemiological research assessment of endpoints is often conducted via registers. In the present study we validated stroke and transient ischemic attack (TIA) diagnoses in the Danish National Register of Patients (DNRP). Methods: Subjects from a Danish cohort study, the Copenhagen City Heart Study (n = 19,698), were crosslinked with the DNRP. The following International Classification of Disease 10th revision codes were used to identify possible strokes and TIAs: I60–I69 and G45. Two independent raters reviewed all cases. Positive predictive values of stroke, TIA and stroke subtypes were estimated by dividing the confirmed cases by the total number of cases located in the DNRP. Interrater reliability was tested using ĸ statistics. Results: Of 236 possible cerebrovascular events, 1 in 6 stroke diagnoses did not meet study criteria. The majority of events in the DNRP were registered as unspecified stroke (I64), n = 105 (44%), of which two thirds were diagnosed as ischemic stroke events by the raters. Intracerebral hemorrhage and ischemic stroke had a positive predictive value from 74 to 97%, respectively. Conclusion: Our results show that the DNRP tends to overestimate the number of cerebrovascular events, while ischemic stroke is underestimated.
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              PLACEBO-CONTROLLED, RANDOMISED TRIAL OF WARFARIN AND ASPIRIN FOR PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN CHRONIC ATRIAL FIBRILLATION

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                Author and article information

                Journal
                Stroke
                Stroke
                Ovid Technologies (Wolters Kluwer Health)
                0039-2499
                1524-4628
                July 2016
                July 2016
                : 47
                : 7
                : 1727-1733
                Affiliations
                [1 ]From the Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark (J.S., E.H.P., M.S., L.P., V.W.H.); Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus N, Denmark (J.S., M.S., H.E.B.); and Departments of Health Research and Policy (Epidemiology) (V.W.H., H.T.S.) and Neurology and Neurological Sciences (V.W.H.), Stanford University, Stanford, CA.
                Article
                10.1161/STROKEAHA.116.013321
                27301935
                31694f5a-1d52-4002-8d23-12b1c0de735a
                © 2016
                History

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