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      Building memories: remembering and forgetting of verbal experiences as predicted by brain activity.

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          Abstract

          A fundamental question about human memory is why some experiences are remembered whereas others are forgotten. Brain activation during word encoding was measured using blocked and event-related functional magnetic resonance imaging to examine how neural activation differs for subsequently remembered and subsequently forgotten experiences. Results revealed that the ability to later remember a verbal experience is predicted by the magnitude of activation in left prefrontal and temporal cortices during that experience. These findings provide direct evidence that left prefrontal and temporal regions jointly promote memory formation for verbalizable events.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Aug 21 1998
          : 281
          : 5380
          Affiliations
          [1 ] Massachusetts General Hospital NMR Center, Harvard Medical School, Charlestown, MA 02129, USA. adwagner@nmr.mgh.harvard.edu
          Article
          10.1126/science.281.5380.1188
          9712582
          3170b69a-88b0-4f1d-a2ec-9eb16f828923
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