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      Metastasis: a question of life or death.

      1 ,
      Nature reviews. Cancer
      Springer Science and Business Media LLC

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          Abstract

          The metastatic process is highly inefficient--very few of the many cells that migrate from the primary tumour successfully colonize distant sites. One proposed mechanism to explain this inefficiency is provided by the cancer stem cell model, which hypothesizes that micrometastases can only be established by tumour stem cells, which are few in number. However, recent in vitro and in vivo observations indicate that apoptosis is an important process regulating metastasis. Here we stress that the inhibition of cell death, apart from its extensively described function in primary tumour development, is a crucial characteristic of metastatic cancer cells.

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-175X
          1474-175X
          Jun 2006
          : 6
          : 6
          Affiliations
          [1 ] Apoptosis, Cancer and Development Laboratory-Equipe labellisée La Ligue, CNRS FRE2870, Centre Léon Bérard, Université Claude Bernard Lyon 1, 69008 Lyon, France. mehlen@lyon.fnclcc.fr
          Article
          nrc1886
          10.1038/nrc1886
          16723991
          31724028-933c-4d66-b96a-4b900e495b0c
          History

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