7
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Effecto de la diarrea inducida con lactosa sobre la disponibilida de los macronutrientes y la función inmune en ratas nutridas y desnutridas

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          El objetivo de este trabajo fue estudiar el efecto del estado nutricional sobre la disponibilidad de los nutrientes dietarios y algunos aspectos del sistema inmunológico durante la diarrea. Para ello se utilizaron ratas a las que se les indujo una diarrea osmótica usando lactosa y desnutrición reduciendo la oferta de dieta a la mitad del consumo registrado en ratas que recibieron alimentación ad libitum. El estudio incluyó cuatro grupos de ratas con siete ratas en cada grupo. Los dos primeros grupos incluyeron ratas nutridas, a uno de ellos se les indujo diarrea y al otro no; el tercer y cuarto grupo incluyeron ratas desnutridas con y sin diarrea, respectivamente. Los resultados mostraron que la lactosa produjo diarrea tanto en las ratas nutridas como en las desnutridas; sin embargo, en las nutridas la diarrea produjo una reducción importante en el consumo de alimento y en el crecimiento, mientras que en las desnutridas no. Así mismo, en las ratas nutridas la diarrea produjo una reducción en la digestibilidad y retención de todos los macronutrientes estudiados, mientras que esta reducción fue menos aparente o no se observó en las ratas desnutridas. Una situación similar se presentó en relación con el peso del timo y la concentración de inmunoglobulina G sérica. En ambos casos la diarrea tuvo un efecto negativo en las ratas nutridas, mientras que en las desnutridas no produjo un deterioro adicional al producido por la desnutrición. En general estos resultados muestran que en las ratas desnutridas no se presentan o se presentan con mucho menos intensidad los efectos negativos de la diarrea. Esta adaptación evita que la diarrea provoque un deterioro adicional en su estado nutricional. (CONICIT,S1-2265).

          Translated abstract

          Effect oflactose induced diarrhea on macronutrients digestibility and immune function in well-nourished a undernourished rats. In this study we compared the availability nutrients in a balanced diet offered to young well-nourished and undemourished Sprague Dawley rats, with and without diarrhea. Malnutrition was induced by restricting food intake (50%) in on half of the rats for 2 weeks and diarrhea was induced by including 45% lactose in the diet after malnutrition had been established. During the experiment which lasted 8 d the animals were kept on the same feeding protocol but one half of the nourished and one half of undernourished received lactose to induce diarrhea. The results showed that the inclusion of lactose at 45% in the diet caused a severe diarrhea both in the nourished and undernourished rats. This diarrhea however, resulted in a reduction in food intake and growth only in well-nourished rats. In the rats with diarrhea the apparent digestibility of the diet and of its macronutrients decreased compared with the animals without diarrhea but this reduction was less apparent in undemourished rats. Similar results were obtained in relation to the retention of nitrogen and energy. In this case, diarrhea was associated with retentions which were lower than those seen in the rats without diarrhea but the undemourished rats with diarrhea retained more energy than the well-nourished rats with diarrhea. Malnutrition resulted in lower packed cell volume, leukocyte count and thyms weight but diarrhea in the malnourished rats did not cause a further reduction in these variables as it did in the well-nourished animals. In general, these results indicate that in well-nourished rats, diarrhea had a negative effect whereas in the undemourished group it did not. It appears that the undemourished rats compensated their nutrient utilization so that diarrhea did not worsen their undernourished condition.

          Related collections

          Most cited references41

          • Record: found
          • Abstract: not found
          • Article: not found

          Immunochemical quantitation of antigens by single radial immunodiffusion.

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Report of the American Institute of Nurtition ad hoc Committee on Standards for Nutritional Studies.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Increased virulence of coxsackievirus B3 in mice due to vitamin E or selenium deficiency.

              Nutrition has long been known to affect the ability of the host to respond to infectious disease. Widespread famines are often accompanied by increased morbidity and mortality due to infectious diseases. The currently accepted view of the relationship between nutrition of the host and its susceptibility to infectious disease is one of a direct relationship with host immune status. That is, if the nutritional status of the host is poor-due to either single or multiple nutrient deficiencies-then the functioning of the host immune system is compromised. This impairment of the immune response will lead to an increased susceptibility to infectious disease. Clearly, the immune response has been shown to be weakened by inadequate nutrition in many model systems and in human studies. However, what about the effect of host nutrition on the pathogen itself? Our laboratory has shown, using a mouse model of coxsackievirus-induced myocarditis, that a host deficiency in either selenium or vitamin E leads to a change in viral phenotype, such that an avirulent strain of the virus becomes virulent and a virulent strain becomes more virulent. The change in phenotype was shown to be due to point mutations in the viral genome. Once the mutations occur, the phenotype change is stable and can now be expressed even in mice of normal nutriture. Our results suggest that nutrition can affect not only the host, but the pathogen as well, and demonstrate a new model of relating host nutritional effects to viral pathogenesis.
                Bookmark

                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Journal
                alan
                Archivos Latinoamericanos de Nutrición
                ALAN
                Sociedad Latinoamericana de Nutrición (Caracas )
                0004-0622
                March 2000
                : 50
                : 1
                : 48-54
                Affiliations
                [1 ] Universidad Simon Bolivar Venezuela
                Article
                S0004-06222000000100006
                3184d87d-1f65-40a1-8549-7ffeb0e4f93f

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Venezuela

                Self URI (journal page): http://www.scielo.org.ve/scielo.php?script=sci_serial&pid=0004-0622&lng=en
                Categories
                NUTRITION & DIETETICS

                Nutrition & Dietetics
                Diarrhea,immune response,lactase,macronutrient absorption,nutritional status,Diarrea,desnutrición,digestibilidad,energía,inmunidad,inmunoglobulina G,lactosa,leucocitos,macronutrientes,timo

                Comments

                Comment on this article