The effect of concentrated growth factors in the treatment of periodontal intrabony defects

Abstract

Aim:

To investigate the effect of concentrated growth factors (CGFs) in human intrabony defect treatment.

Methods:

Thirty-one intrabony defects were randomly treated with CGFs + bovine porous bone mineral (BPBM) or BPBM alone. Probing depth, clinical attachment level and hard tissue fill were evaluated at baseline and 1 year post surgery.

Results:

No differences in any of the investigated parameters were observed at baseline. At 1 year post therapy, both groups showed significant improvement in clinical parameters (p < 0.001). CGFs + BPBM was more effective than BPBM alone at decreasing probing depth (4.2 ± 1.3 mm vs 3.0 ± 1.6 mm) and clinical attachment level gain (3.7 ± 1.3 mm vs 2.4 ± 1.1 mm; p ≤ 0.05). A favorable increase of hard tissue fill was noted in CGFs + BPBM group compared with BPBM group (p > 0.05). The contents of growth factors in CGFs were statistically higher than those in platelet poor plasma (p < 0.001).

Conclusion:

Addition of CGFs significantly improved clinical effectiveness of BPBM for intrabony defect treatment.

Lay abstract

Concentrated growth factors (CGFs) are a new generation of platelets concentrates, which contain abundant growth factors. We assumed that CGFs might promote periodontal (gum) regeneration. In the present study, we used CGFs in the treatment of periodontal intrabony defects. The results at 1 year post surgery indicated that the addition of CGFs significantly improved the clinical effectiveness of bone graft alone. More research is needed to better understand this effect.