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Innate immunity: an overview
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Abstract
Though sometimes portrayed as "new," the science of innate immunity made its start
more than 100 years ago. Recent progress has reflected the application of new methods
to old problems. In particular, genetic dissection of innate immune pathways has been
pursued with great success in model organisms. This has opened the way to an understanding
of innate immune sensing. The effector arm of innate immunity has also been tackled,
largely though the use of biochemical methods.