29
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Dietary therapy mitigates persistent wake deficits caused by mild traumatic brain injury.

      Science translational medicine
      Amino Acids, Branched-Chain, therapeutic use, Animals, Behavior, Animal, Brain Injuries, diet therapy, Cognition, Cognitive Therapy, Disease Models, Animal, Electroencephalography, Glutamic Acid, metabolism, Intracellular Signaling Peptides and Proteins, Male, Mice, Mice, Inbred C57BL, Neurons, drug effects, Neuropeptides, Wakefulness, physiology

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Sleep disorders are highly prevalent in patients with traumatic brain injury (TBI) and can significantly impair cognitive rehabilitation. No proven therapies exist to mitigate the neurocognitive consequences of TBI. We show that mild brain injury in mice causes a persistent inability to maintain wakefulness and decreases orexin neuron activation during wakefulness. We gave mice a dietary supplement of branched-chain amino acids (BCAAs), precursors for de novo glutamate synthesis in the brain. BCAA therapy reinstated activation of orexin neurons and improved wake deficits in mice with mild brain injury. Our data suggest that dietary BCAA intervention, acting in part through orexin, can ameliorate injury-induced sleep disturbances and may facilitate cognitive rehabilitation after brain injury.

          Related collections

          Author and article information

          Comments

          Comment on this article