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      Acupuncture in Menopause (AIM) study : a pragmatic, randomized controlled trial

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          Abstract

          The aim of the study was to evaluate the short and long-term effects of acupuncture on vasomotor symptoms (VMS) and quality of life-related measures.

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          Most cited references39

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          Executive summary: Stages of Reproductive Aging Workshop (STRAW).

          A select group of investigators attended a structured workshop, the Stages of Reproductive Aging Workshop (STRAW), at Park City, Utah, USA, in July 2001, which addressed the need in women for a staging system as well as the confusing nomenclature for the reproductive years.
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            Effects of estrogen plus progestin on health-related quality of life.

            The Women's Health Initiative (WHI) and other clinical trials indicate that significant health risks are associated with combination hormone use. Less is known about the effect of hormone therapy on health-related quality of life. The WHI randomly assigned 16,608 postmenopausal women 50 to 79 years of age (mean, 63) with an intact uterus at base line to estrogen plus progestin (0.625 mg of conjugated equine estrogen plus 2.5 mg of medroxyprogesterone acetate, in 8506 women) or placebo (in 8102 women). Quality-of-life measures were collected at base line and at one year in all women and at three years in a subgroup of 1511 women. Randomization to estrogen plus progestin resulted in no significant effects on general health, vitality, mental health, depressive symptoms, or sexual satisfaction. The use of estrogen plus progestin was associated with a statistically significant but small and not clinically meaningful benefit in terms of sleep disturbance, physical functioning, and bodily pain after one year (the mean benefit in terms of sleep disturbance was 0.4 point on a 20-point scale, in terms of physical functioning 0.8 point on a 100-point scale, and in terms of pain 1.9 points on a 100-point scale). At three years, there were no significant benefits in terms of any quality-of-life outcomes. Among women 50 to 54 years of age with moderate-to-severe vasomotor symptoms at base line, estrogen and progestin improved vasomotor symptoms and resulted in a small benefit in terms of sleep disturbance but no benefit in terms of the other quality-of-life outcomes. In this trial in postmenopausal women, estrogen plus progestin did not have a clinically meaningful effect on health-related quality of life. Copyright 2003 Massachusetts Medical Society
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              Neurochemical basis of acupuncture analgesia.

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                Author and article information

                Journal
                Menopause
                Menopause
                Ovid Technologies (Wolters Kluwer Health)
                1072-3714
                2016
                June 2016
                : 23
                : 6
                : 626-637
                Article
                10.1097/GME.0000000000000597
                4874921
                27023860
                31c01a90-e218-414c-8b8c-b5b658702025
                © 2016
                History

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