Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts.

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Abstract

This study aims to investigate the effect of alpha-mangostin on interleukin (IL)-6 and IL-8 expression in human gingival fibroblasts (HGFs). HGFs were challenged with Porphyromonas gingivalis LPS and then treated with various concentrations of alpha-mangostin. The cytotoxicity was determined using MTS assay and cytokine expressions were evaluated by Real-time PCR and ELISA. The results showed that 5 μg/ml P. gingivalis LPS and alpha-mangostin at 1 µg/ml or less did not affect the viability of HGFs. Alpha-mangostin reduced IL-6 and IL-8 mRNA and protein in P. gingivalis LPS-stimulated HGFs. These findings suggested that alpha-mangostin might be used as an adjunct to the periodontal therapy.

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Journal

Journal ID (iso-abbrev): Odontology

Title: Odontology

Publisher: Springer Nature America, Inc

ISSN (Electronic): 1618-1255

ISSN (Print): 1618-1247

Publication date (Electronic): Sep 2015

Volume: 103

Issue: 3

Affiliations

[1 ] Departments of Preventive Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, 65000, Thailand. ichayak@yahoo.com.

[2 ] Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok, 65000, Thailand.

Article

Publisher Item ID: 10.1007/s10266-014-0160-7

DOI: 10.1007/s10266-014-0160-7

PubMed ID: 24888491

SO-VID: 31ced715-5bb8-4449-b627-d3626c481a95

History

Keywords: HGFs,IL-6/8,Alpha-mangostin

Data availability:

Keywords: HGFs, IL-6/8, Alpha-mangostin

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