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      Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

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          Abstract

          Eosinophilia is associated with worsening asthma severity and decreased lung function, with increased exacerbation frequency. We assessed the safety and efficacy of benralizumab, a monoclonal antibody against interleukin-5 receptor α that depletes eosinophils by antibody-dependent cell-mediated cytotoxicity, for patients with severe, uncontrolled asthma with eosinophilia.

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          Author and article information

          Journal
          The Lancet
          The Lancet
          Elsevier BV
          01406736
          October 2016
          October 2016
          : 388
          : 10056
          : 2115-2127
          Article
          10.1016/S0140-6736(16)31324-1
          27609408
          © 2016

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