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      Cytotoxic xenia diterpenoids from the soft coral Xenia umbellata.

      Journal of Natural Products
      Animals, Anthozoa, chemistry, Antineoplastic Agents, isolation & purification, pharmacology, Diterpenes, Drug Screening Assays, Antitumor, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Taiwan, Tumor Cells, Cultured

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          Abstract

          Eleven new xenia diterpenoids, umbellacins A-G (1-7), 14,15-epoxy-xeniolide H (8), 3-acetyl-14,15-epoxy-xeniolide H (9), and umbellacins H and I (10, 11), were isolated from a methylene chloride-soluble fraction of the soft coral Xenia umbellata. The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

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