Blog
About

107
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Osteoclast differentiation and activation.

      Nature

      Signal Transduction, Receptors, Tumor Necrosis Factor, metabolism, Receptors, Cytoplasmic and Nuclear, Receptor Activator of Nuclear Factor-kappa B, RANK Ligand, Osteoprotegerin, drug therapy, Osteoporosis, cytology, Osteoclasts, Membrane Glycoproteins, Humans, Glycoproteins, Cell Differentiation, Carrier Proteins, Bone Resorption, Animals

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis and activation of bone resorption, and how hormonal signals impact bone structure and mass. Further study of this pathway is providing the molecular basis for developing therapeutics to treat osteoporosis and other diseases of bone loss.

          Related collections

          Author and article information

          Journal
          10.1038/nature01658
          12748652

          Comments

          Comment on this article