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      Vitisin B as a novel fatty acid synthase inhibitor induces human breast cancer cells apoptosis

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          Abstract

          Breast cancer is one of the most common cancers and the second leading cause of cancer mortality in women worldwide. Novel therapies and chemo-therapeutic drugs are still in urgent need to be developed for the treatment of breast cancer. One of the most important metabolic hallmarks of breast cancer cells is enhanced lipogenesis. Increasing evidences suggest that fatty acid synthase (FAS) plays an important role in the development of human breast cancer, for the expression of FAS is significantly higher in breast cancer cells than in normal cells. In addition, FAS inhibitors, such as curcumin, ursolic acid, and resveratrol, have shown anti-cancer potential. In the present study, we discovered that vitisin B, a natural stilbene isolated from the seeds of Iris lactea Pall. var. chinensis (Fisch.), was a novel FAS inhibitor. We found that vitisin B could down-regulate FAS expression and inhibit intracellular FAS activity in MDA-MB-231 cells. Also, we reported for the first time that vitisin B exhibited apoptotic effect on human breast cancer cells. Given all of this, we proposed a hypothesis that vitisin B has an application potential in the chemoprevention and treatment of breast cancer.

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          Author and article information

          Journal
          Am J Transl Res
          Am J Transl Res
          ajtr
          American Journal of Translational Research
          e-Century Publishing Corporation
          1943-8141
          2019
          15 August 2019
          : 11
          : 8
          : 5096-5104
          Affiliations
          [1 ] College of Life Sciences, University of Chinese Academy of Sciences No. 19A Yuquan Road, Beijing 100049, China
          [2 ] School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 311402, China
          [3 ] School of Kinesiology and Health, Capital University of Physical Education and Sports No. 11 Beisanhuanxi Road, Beijing 100191, China
          Author notes
          Address correspondence to: Xiaofeng Ma, College of Life Sciences, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. Tel: +8610-88256585; Fax: +8610-88256585; E-mail: maxiaofeng@ 123456ucas.ac.cn ; Xiaoyan Wang, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China. Tel: +86571-61768525; Fax: +86571-61768525; E-mail: xy.wang@ 123456zcmu.edu.cn ; Yan Liang, School of Kinesiology and Health, Capital University of Physical Education and Sports, No. 11 Beisanhuanxi Road, Beijing 100191, China. Tel: 8610-82099150; Fax: +8610-82099150; E-mail: yanliang@ 123456cupes.edu.cn
          [*]

          Equal contributors.

          Article
          PMC6731432 PMC6731432 6731432
          6731432
          31497225
          31e1f355-6544-48ae-88e2-4be8bdadf638
          AJTR Copyright © 2019
          History
          : 15 November 2018
          : 23 May 2019
          Categories
          Original Article

          stilbene,breast cancer cell,apoptosis,vitisin B,Fatty acid synthase,inhibitor

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