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Abstract
<p class="first" id="d3101810e134">It has been demonstrated in previous studies that
lncPART1 is dysregulated in non-small
cell lung cancer (NSCLC). However, the function of lncPART1 in NSCLC is unclear. Therefore,
this experimental design was based on LncPART1 to explore the pathogenesis of NSCLC.
Real-time polymerase chain reaction was used to detect the expression of lncPART1
and miR-17-5p in NSCLC. Cell Counting Kit -8, colony formation, and transwell assays
were used to examine the effects of lncPART1 and miR-17-5p on NSCLC cell proliferation
and migration invasiveness. Target gene prediction, luciferase reporter assays were
used to validate downstream target genes for lncPART1 and miR-17-5p. Western blot
analysis was used to detect the expression of TGFBETAR2. LncPART1 was highly expressed
in NSCLC. LncPART1 significantly promoted cell proliferation of NSCLC cells. miR-17-5p
was down-expressed in NSCLC. miR-17-5p overexpression inhibited cell proliferation
and migration invasion in NSCLC cells. LncPART1 was able to inhibit miR-17-5p expression
and upregulate the expression level of TGFBETAR2. The results of in vivo animal models
confirmed that lncPART1 promoted NSCLC progression by miR-17-5p/TGFBETAR2 axis. LncPART1
promoted the progression of NSCLC by miR-17-5p/TGFBETAR2 axis.
</p>