肺癌术后短期中链甘油三酯饮食临床效果的前瞻性随机研究 Translated title: What is Result: Short-term Medium Chain Triglyceride Diet Effective on Postoperative Outcome in Lung Cancer Surgery? A Prospective Randomized Study

Abstract

背景与目的

中链甘油三酯(medium chain triglyceride, MCT)饮食有助于外科手术患者快速康复，本研究将短期MCT食谱应用于肺癌患者术后早期饮食，探讨肺癌患者术后应用MCT的临床效果。

方法

2015年12月-2016年3月四川大学华西胸外科单个医疗组肺癌切除术患者纳入研究患者117例，随机分为MCT组(62例)和常规饮食组(routine diet group, RDG)(55例)。分析两组患者术后白蛋白、肛门排气时间、胸腔闭式引流量及胸腔闭式引流管留置时间、术后住院日、住院费用。

结果

MCT组患者术后肛门排气时间[(27.87±14.38) h]短于RDG组[(45.18±8.62) h]( P < 0.001)；术后胸腔引流管留置时间在MCT组[(75.40±48.41) h]少于RDG组[(110.64±94.19) h]( P=0.025)；术后胸腔引流量在MCT[395mL]组少于RDG组[590mL]( P=0.027)。术后住院日在MCT组[(5.26±2.96) d)]短于RDG组[(6.73±3.99) d]( P=0.030)。血浆白蛋白术后MCT组[(37.26±2.70) g/L]高于RDG组[(35.92±3.12) g/L]( P=0.023)。

结论

肺癌患者术后短期应用MCT饮食有助于改善胃肠功能快速恢复，且缩短术后住院时间。

Translated abstract

Background and objective

It has been proven that medium chain triglyceride (MCT) diet was contribute to fast track recovery after surgery in patients with operation. In this study, the benefit of postoperative short term MCT diet support was investigated for non-small cell lung cancer patients who underwent anatomic resection.

Methods

A prospective study was planned with the approval of our institutional review board. 117 lung cancer patients who underwent anatomic resection in a single medical group between December 2015 and March 2016 were randomized. 62 patients were applied a MCT diet. and 55 patients in the control group who were fed with only normal diet, and the serum albumin levels, anus exhaust time, chest drainage, chest drainage time, the hospitalization time of post operation, average hospital cost were analysed.

Results

The mean anus exhaust time in MCT group [(27.87±14.38) h] was significantly shorter than that in RDG group [(45.18±8.62) h] ( P < 0.001); The mean chest tube drainage time in MCT group [(75.40±48.41) h] were less than that in RDG group [(110.64±94.19) h] ( P=0.025). The mean chest tube drainage volume in MCT group [395 mL] were less than that in RDG group [590 mL] ( P=0.027). The hospitalization time of post operation was (5.26±2.96) d in MCT group against (6.73±3.99) d in RGD group ( P=0.030). The serum albumin levels of postoperative in MCT group [(37.26±2.70) g/L)] was significantly higher than that in RDG group [(35.92±3.12) g/L)] ( P=0.023).

Conclusions

The results of this study demonstrated that postoperative short term MCT diet is beneficial in postoperative gastrointestinal function fast recovered and shorten the hospitalization time in non-small cell lung cancer patients after surgery.