6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Origin of antiphospholipid antibodies: induction of aPL by viral peptides.

      1 ,

      Lupus

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The clinical associations of antiphospholipid antibodies (aPL) are well recognized but the mechanism(s) causing the production of these antibodies are not yet known. We demonstrated the induction of pathogenic aPL antibodies that caused intrauterine fetal death and transverse myelopathy due to spinal cord infarction in mice by immunization with foreign beta2GPI. We also induced aPL and anti-beta2-GPI in mice by immunization with PL-binding viral peptides and hypothesized that in APS patients, aPL may be induced by beta2GPI-like-PL-binding products of common human bacteria and viruses.

          Related collections

          Author and article information

          Journal
          Lupus
          Lupus
          0961-2033
          0961-2033
          1998
          : 7 Suppl 2
          Affiliations
          [1 ] Morehouse School of Medicine, Department of Medicine, Atlanta, GA 30310-1495, USA. AGHARA@POL.NET
          Article
          9814674

          Comments

          Comment on this article