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      Malformaciones congénitas relacionadas con los agentes teratógenos Translated title: Congenital malformations related to teratogenic agents

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          Abstract

          Los agentes teratógenos constituyen un problema social, pues no todos los pacientes que nacen con alguna malformación congénita logran bienestar absoluto, pues arrastran secuelas que repercuten en la calidad de vida. Muchas drogas, medicamentos y sustancias químicas atraviesan la barrera placentaria y causan efectos adversos sobre el embrión o el feto. Se realizó una actualización en cuanto a la toxicología del desarrollo prenatal. Se revisaron 186 resúmenes bibliográficos de PubMed, Scielo,Foxitsoftware, Latinsalud, Infomed y libros de la especialidad de embriología, de los que se seleccionaron 64 con criterios de relevancia científica, actualidad y autor. Se desecharon 31 repetidos y quedaron solo 35, en las cuales se centró el trabajo. Todo esto evidenció la existencia de diversas drogas, medicamentos, sustancias químicas, exposiciones ocupacionales y del medio ambiente que constituyen embriotóxicos, capaces de producir defectos congénitos con riesgo de mortalidad durante la vida intrauterina, en el período perinatal y las etapas tempranas de la vida.

          Translated abstract

          Teratogenic agents have become a social problem. Many drugs, medications and chemical substances can cross the placental barrier, with adverse effects on embryo or fetus. Patients born with congenital malformations have sequelae that influence their life quality. A bilbliographic rewiew about antenatal toxicology trough Latinsalud, Infomed and embryology books. We picked a group of 64 with scientific criteria, publication and author. We discarded 31 repeated, checked 186 bibliographic PubMed's summaries, Scielo, foxitsoftware themselves. Finally there were only 35 publications, in which various drugs, medications, chemical substances, occupational and the ambient- midway expositions were considered capable toxics to produce congenital defects, with a high mortality range during the intrauterine life, in the perinatal period and in premature life stages.

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          Most cited references27

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          Malformaciones Congénitas Asociadas a Agrotóxicos

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            Metal Contamination and the Epidemic of Congenital Birth Defects in Iraqi Cities

            Between October 1994 and October 1995, the number of birth defects per 1,000 live births in Al Basrah Maternity Hospital was 1.37. In 2003, the number of birth defects in Al Basrah Maternity Hospital was 23 per 1,000 live births. Within less than a decade, the occurrence of congenital birth defects increased by an astonishing 17-fold in the same hospital. A yearly account of the occurrence and types of birth defects, between 2003 and 2011, in Al Basrah Maternity Hospital, was reported. Metal levels in hair, toenail, and tooth samples of residents of Al Basrah were also provided. The enamel portion of the deciduous tooth from a child with birth defects from Al Basrah (4.19 μg/g) had nearly three times higher lead than the whole teeth of children living in unimpacted areas. Lead was 1.4 times higher in the tooth enamel of parents of children with birth defects (2,497 ± 1,400 μg/g, mean ± SD) compared to parents of normal children (1,826 ± 1,819 μg/g). Our data suggested that birth defects in the Iraqi cities of Al Basrah (in the south of Iraq) and Fallujah (in central Iraq) are mainly folate-dependent. This knowledge offers possible treatment options and remediation plans for at-risk Iraqi populations.
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              Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy — Brazil, 2015

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Journal
                ccm
                Correo Científico Médico
                ccm
                Universidad Ciencias Médicas de Holguín (Holguín, , Cuba )
                1560-4381
                December 2018
                : 652-666
                Affiliations
                [01] Holguín orgnameUniversidad de Ciencias Médicas de Holguín orgdiv1Facultad de Ciencias Médicas Mariana Grajales Coello Cuba
                [02] La Habana orgnameFacultad de Tecnología de la Salud (FATESA). Cuba
                Article
                S1560-43812018000400011
                31f780fe-e9f4-4ffa-9826-6e0ce315e0b6

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 12 December 2016
                : 16 February 2017
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 35, Pages: 15
                Product

                SciELO Cuba


                teratógenos,congenital abnormalities,congenital malformations,teratogens,anomalías congénitas,malformaciones congénitas

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