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      Electrical Sensing of Au Nanoparticles Manipulated by an Optical Vortex

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          A revolution in optical manipulation.

          Optical tweezers use the forces exerted by a strongly focused beam of light to trap and move objects ranging in size from tens of nanometres to tens of micrometres. Since their introduction in 1986, the optical tweezer has become an important tool for research in the fields of biology, physical chemistry and soft condensed matter physics. Recent advances promise to take optical tweezers out of the laboratory and into the mainstream of manufacturing and diagnostics; they may even become consumer products. The next generation of single-beam optical traps offers revolutionary new opportunities for fundamental and applied research.
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            Observation of a single-beam gradient force optical trap for dielectric particles

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              The potential and challenges of nanopore sequencing.

              A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore. The nanopore provides a highly confined space within which single nucleic acid polymers can be analyzed at high throughput by one of a variety of means, and the perfect processivity that can be enforced in a narrow pore ensures that the native order of the nucleobases in a polynucleotide is reflected in the sequence of signals that is detected. Kilobase length polymers (single-stranded genomic DNA or RNA) or small molecules (e.g., nucleosides) can be identified and characterized without amplification or labeling, a unique analytical capability that makes inexpensive, rapid DNA sequencing a possibility. Further research and development to overcome current challenges to nanopore identification of each successive nucleotide in a DNA strand offers the prospect of 'third generation' instruments that will sequence a diploid mammalian genome for approximately $1,000 in approximately 24 h.
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                Author and article information

                Contributors
                (View ORCID Profile)
                (View ORCID Profile)
                Journal
                The Journal of Physical Chemistry C
                J. Phys. Chem. C
                American Chemical Society (ACS)
                1932-7447
                1932-7455
                May 06 2021
                April 27 2021
                May 06 2021
                : 125
                : 17
                : 9507-9515
                Affiliations
                [1 ]Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan
                [2 ]Global Center for Medical Engineering and Informatics, Osaka University, Suita, Osaka 565-0871, Japan
                [3 ]Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi, Aichi 441-8580, Japan
                Article
                10.1021/acs.jpcc.1c01804
                320090b1-a963-48f9-b53b-8759b9c61728
                © 2021
                History

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