Metal nanoparticles: understanding the mechanisms behind antibacterial activity

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Abstract

As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.

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Most cited references 78

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Author and article information

Contributors

Yael N. Slavin: yaelnicoleslavin@gmail.com

Jason Asnis: jason.asnis@mail.mcgill.ca

Urs O. Häfeli: urs.hafeli@ubc.ca

Horacio Bach: hbach@mail.ubc.ca

Journal

Journal ID (nlm-ta): J Nanobiotechnology

Journal ID (iso-abbrev): J Nanobiotechnology

Title: Journal of Nanobiotechnology

Publisher: BioMed Central (London )

ISSN (Electronic): 1477-3155

Publication date (Electronic): 3 October 2017

Publication date PMC-release: 3 October 2017

Publication date Collection: 2017

Volume: 15

Electronic Location Identifier: 65

Affiliations

[1 ]ISNI 0000 0001 2288 9830, GRID grid.17091.3e, Department of Medicine, Division of Infectious Diseases, , University of British Columbia, ; 410-2660 Oak St., Vancouver, BC V6H3Z6 Canada

[2 ]ISNI 0000 0001 2288 9830, GRID grid.17091.3e, Faculty of Pharmaceutical Sciences, , University of British Columbia, ; Vancouver, BC Canada

Article

Publisher ID: 308

DOI: 10.1186/s12951-017-0308-z

PMC ID: 5627441

PubMed ID: 28974225

SO-VID: 3214f809-6904-4d55-9135-f9c023f774c4

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 3 July 2017

Date accepted : 25 September 2017

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100000032, Institute of Infection and Immunity;

Award ID: 01369- 000

Award Recipient : Horacio Bach

Custom metadata

ScienceOpen disciplines: Biotechnology

Keywords: nanoparticles,metals,ros,mechanism of defense,bacteria,transcriptomics,proteomics,gene regulation,antibacterial resistance

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ScienceOpen disciplines: Biotechnology

Keywords: nanoparticles, metals, ros, mechanism of defense, bacteria, transcriptomics, proteomics, gene regulation, antibacterial resistance

Metal nanoparticles: understanding the mechanisms behind antibacterial activity

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Microbiology Independent Research Journal (MIR Journal)

Most cited references 78

The green fluorescent protein.

Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.

Nanoparticle-based targeted drug delivery.

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