Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity

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Highlights

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A relationship between infecting dose and risk of disease severity has not been demonstrated for COVID-19.
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We report three clusters of COVID-19 in Madrid, in which infected persons experienced different disease severity according to distinct sizes of viral inoculum.
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Smaller viral inoculi as a result of wide social distancing would contribute to the lower pathogenicity of recent SARS-CoV-2 infections.

Abstract

A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were exposed to diverse inoculi in Madrid and overall developed divrgent clinical forms of COVID-19. Our data support that a greater SARS-CoV-2 inoculi at the time of exposure might determine a higher risk of severe COVID-19.

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Author and article information

Contributors

Vicente Soriano

Journal

Journal ID (nlm-ta): Int J Infect Dis

Journal ID (iso-abbrev): Int. J. Infect. Dis

Title: International Journal of Infectious Diseases

Publisher: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

ISSN (Print): 1201-9712

ISSN (Electronic): 1878-3511

Publication date PMC-release: 14 June 2020

Publication date (Electronic): 14 June 2020

Affiliations

[a ]Department of Preventive Medicine, Public Health & Microbiology, Medical School, Universidad Autónoma de Madrid, Madrid, Spain

[b ]IdiPAZ & CIBER Epidemiology & Public Health (CIBERESP) & IMDEA-Food Institute, CEI UAM-CSIC, Madrid, Spain

[c ]Oncology Department, Clínica Universitaria de Navarra, Madrid, Spain

[d ]Department of Preventive Medicine, Public Health & Microbiology, Universidad Autónoma de Madrid, Madrid, Spain

[e ]Nutritional and Cardiovascular Epidemiology Unit, Environmental Medicine Institute (IMM), Karolinska Institute, Stockholm, Sweden

[f ]Health Sciences School, UNIR, Madrid, Spain

[g ]Genetics Department, Alcalá University, Madrid, Spain

[h ]Medical Center & Health Sciences School, UNIR, Madrid, Spain

Author notes

[* ]Corresponding author at: UNIR Health Sciences School & Medical Center, Calle Almansa 101, Madrid 28040, Spain. vicente.soriano@ 123456unir.net

Article

Publisher ID: S1201-9712(20)30470-7

DOI: 10.1016/j.ijid.2020.06.035

PMC ID: 7293836

PubMed ID: 32553720

SO-VID: 3220722c-d30a-4d2c-b76c-df1f5565081d

License:

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

History

Date received : 26 May 2020

Date revision received : 8 June 2020

Date accepted : 10 June 2020

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