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      Inhibition of Barium-Induced Constriction of Cerebral Surface Arterioles by Blockers of Calcium Channels

      Journal of Vascular Research

      S. Karger AG

      Pial microcirculation, Vasoconstriction, Barium ion, Calcium channels

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          Barium ion, applied as BaCl<sub>2</sub> to the cerebral surface, produces marked constriction of pial arterioles. The present data demonstrate that this constriction is inhibited by the calcium channel blockers verapamil and nimodipine. Verapamil in concentrations as low as 10–7 M was effective in local administration. Verapamil in milligram per kilogram doses and nimodipine in microgram per kilogram doses were effective 30 min after intraperitoneal injection without producing dilation. The basis for the inhibitory action of the calcium channel blockers is not established by the data. However, in view of barium’s known ability to depolarize membranes, it may be that the constriction which results is related to inward passage of ions and is facilitated by inward movements of calcium.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 22
          : 3
          : 139-144
          Department of Pathology (Neuropathology), Medical College of Virginia, Richmond, Va., USA
          158591 Blood Vessels 1985;22:139–144
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 6
          Research Paper


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