For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
28
views
127
references
 Top references
cited by
324
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      516
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Blautia—a new functional genus with potential probiotic properties?

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          ABSTRACT

          Blautia is a genus of anaerobic bacteria with probiotic characteristics that occur widely in the feces and intestines of mammals. Based on phenotypic and phylogenetic analyses, some species in the genera Clostridium and Ruminococcus have been reclassified as Blautia, so to date, there are 20 new species with valid published names in this genus. An extensive body of research has recently focused on the probiotic effects of this genus, such as biological transformation and its ability to regulate host health and alleviate metabolic syndrome. This article reviews the origin and biological characteristics of Blautia and the factors that affect its abundance and discusses its role in host health, thus laying a theoretical foundation for the development of new functional microorganisms with probiotic properties.

          Related collections

          Most cited references127

          • Record: found
          • Abstract: found
          • Article: not found

          Enterotypes of the human gut microbiome.

          Jan Knol, Omar Lakhdari, Séverine Layec … (2012)
          Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific. We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. This indicates further the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake. The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis to understand microbial communities. Although individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each of these host properties. For example, twelve genes significantly correlate with age and three functional modules with the body mass index, hinting at a diagnostic potential of microbial markers.
          Article 0 comments Cited 1148 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Diversity of the human intestinal microbial flora.

            Paul Eckburg, Elisabeth Bik, Charles Bernstein … (2005)
            The human endogenous intestinal microflora is an essential "organ" in providing nourishment, regulating epithelial development, and instructing innate immunity; yet, surprisingly, basic features remain poorly described. We examined 13,355 prokaryotic ribosomal RNA gene sequences from multiple colonic mucosal sites and feces of healthy subjects to improve our understanding of gut microbial diversity. A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms. We discovered significant intersubject variability and differences between stool and mucosa community composition. Characterization of this immensely diverse ecosystem is the first step in elucidating its role in health and disease.
            Article 0 comments Cited 992 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients.

              H Sokol, B Pigneur, L. Watterlot … (2008)
              A decrease in the abundance and biodiversity of intestinal bacteria within the dominant phylum Firmicutes has been observed repeatedly in Crohn disease (CD) patients. In this study, we determined the composition of the mucosa-associated microbiota of CD patients at the time of surgical resection and 6 months later using FISH analysis. We found that a reduction of a major member of Firmicutes, Faecalibacterium prausnitzii, is associated with a higher risk of postoperative recurrence of ileal CD. A lower proportion of F. prausnitzii on resected ileal Crohn mucosa also was associated with endoscopic recurrence at 6 months. To evaluate the immunomodulatory properties of F. prausnitzii we analyzed the anti-inflammatory effects of F. prausnitzii in both in vitro (cellular models) and in vivo [2,4,6-trinitrobenzenesulphonic acid (TNBS)-induced] colitis in mice. In Caco-2 cells transfected with a reporter gene for NF-kappaB activity, F. prausnitzii had no effect on IL-1beta-induced NF-kappaB activity, whereas the supernatant abolished it. In vitro peripheral blood mononuclear cell stimulation by F. prausnitzii led to significantly lower IL-12 and IFN-gamma production levels and higher secretion of IL-10. Oral administration of either live F. prausnitzii or its supernatant markedly reduced the severity of TNBS colitis and tended to correct the dysbiosis associated with TNBS colitis, as demonstrated by real-time quantitative PCR (qPCR) analysis. F. prausnitzii exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-kappaB activation and IL-8 production. These results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment.
              Article 0 comments Cited 771 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Gut Microbes
                Journal ID (iso-abbrev): Gut Microbes
                Title: Gut Microbes
                Publisher: Taylor & Francis
                ISSN (Print): 1949-0976
                ISSN (Electronic): 1949-0984
                Publication date (Electronic, pub): 1 February 2021
                Publication date (Electronic, collection): 2021
                Publication date PMC-release: 1 February 2021
                Volume: 13
                Issue: 1
                Pages: 1-21
                Affiliations
                [a ]State Key Laboratory of Food Science and Technology, Jiangnan University; , Wuxi, Jiangsu, China
                [b ]School of Food Science and Technology, Jiangnan University; , Wuxi, Jiangsu, China
                [c ]National Engineering Research Center for Functional Food, Jiangnan University; , Wuxi, Jiangsu, China
                [d ]Beijing Innovation Center of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU); , Beijing, China
                Author notes
                Shumao Cui cuishumao@ 123456jiangnan.edu.cn. School of Food Science and Technology, Jiangnan University; , Lihu Avenue 1800, Wuxi214122, China.
                Author information
                https://orcid.org/0000-0002-6342-1254
                Article
                Publisher ID: 1875796
                DOI: 10.1080/19490976.2021.1875796
                PMC ID: 7872077
                PubMed ID: 33525961
                SO-VID: 324fa6e6-82e4-49c1-80fd-81c9e15da411
                Copyright © © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Page count
                Figures: 7, Tables: 5, References: 126, Pages: 21
                Categories
                Subject: Review
                Subject: Review

                ScienceOpen disciplines: Microbiology & Virology
                Keywords: blautia,biotransformation,probiotics,host health
                Data availability:
                ScienceOpen disciplines: Microbiology & Virology
                Keywords: blautia, biotransformation, probiotics, host health

                Comments

                Comment on this article

                scite_

                Similar content516

                See all similar

                Cited by321

                See all cited by

                Most referenced authors2,669

                See all reference authors