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      Fast moment estimation for generalized latent Dirichlet models

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          Abstract

          We develop a generalized method of moments (GMM) approach for fast parameter estimation in a new class of Dirichlet latent variable models with mixed data types. Parameter estimation via GMM has been demonstrated to have computational and statistical advantages over alternative methods, such as expectation maximization, variational inference, and Markov chain Monte Carlo. The key computational advan- tage of our method (MELD) is that parameter estimation does not require instantiation of the latent variables. Moreover, a representational advantage of the GMM approach is that the behavior of the model is agnostic to distributional assumptions of the observations. We derive population moment conditions after marginalizing out the sample-specific Dirichlet latent variables. The moment conditions only depend on component mean parameters. We illustrate the utility of our approach on simulated data, comparing results from MELD to alternative methods, and we show the promise of our approach through the application of MELD to several data sets.

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          Most cited references14

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          Association mapping in structured populations.

          The use, in association studies, of the forthcoming dense genomewide collection of single-nucleotide polymorphisms (SNPs) has been heralded as a potential breakthrough in the study of the genetic basis of common complex disorders. A serious problem with association mapping is that population structure can lead to spurious associations between a candidate marker and a phenotype. One common solution has been to abandon case-control studies in favor of family-based tests of association, such as the transmission/disequilibrium test (TDT), but this comes at a considerable cost in the need to collect DNA from close relatives of affected individuals. In this article we describe a novel, statistically valid, method for case-control association studies in structured populations. Our method uses a set of unlinked genetic markers to infer details of population structure, and to estimate the ancestry of sampled individuals, before using this information to test for associations within subpopulations. It provides power comparable with the TDT in many settings and may substantially outperform it if there are conflicting associations in different subpopulations.
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            Structural equation modeling in practice: A review and recommended two-step approach.

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              Towards a standardized notation and terminology in multiway analysis

              Henk Kiers (2000)
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                Author and article information

                Journal
                2016-03-16
                2016-03-23
                Article
                1603.05324
                325654b9-9b98-400b-ac2f-ac48aa79be0a

                http://arxiv.org/licenses/nonexclusive-distrib/1.0/

                History
                Custom metadata
                corrected a typo in figure
                math.ST cs.LG stat.AP stat.ME stat.TH

                Applications,Artificial intelligence,Methodology,Statistics theory
                Applications, Artificial intelligence, Methodology, Statistics theory

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