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      Contribution of Four Markers of Tubular Proteinuria in Detecting Upper Urinary Tract Infections

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          Abstract

          The presence of tubular involvement, as a marker for the detection of urinary tract infection (UTI) site, was examined in 19 patients with pyelonephritis and in 15 patients with cystitis or asymptomatic bacteriuria. The urinary excretion of four markers of tubular proteinuria, β<sub>2</sub>-microglobulin (β<sub>2</sub>M), lysozyme (LZ), lactic dehydrogenase isoenzyme V (LAD-5) and N-acetyl-β D-glucosaminidase (NAG), was investigated. LAD-5 appeared particularly valuable for the early detection of upper UTI. However, the overall diagnostic accuracy appeared to be further strengthened using, besides LAD-5, one additional variable. A set of simple and noninvasive biochemical tests on urine samples can reliably help to identify the site of UTI.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 32
          : 3
          : 234-238
          Affiliations
          aClinica Medica e bChimica e Microscopia Clinica, Facoltà di Medicina e Chirurgia, Università di Verona, Italia; cLaboratorio di Chimica Clinica, Istituti Ospedalieri di Verona, Italia
          Article
          182851 Nephron 1982;32:234–238
          10.1159/000182851
          6759951
          32789882-e4a5-4c58-966c-cd53494e221f
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 26 May 1982
          Page count
          Pages: 5
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          Beta2microglobulin,Lysozyme,Lactic dehydrogenase isoenzyme V,N-acetyl-β<italic>D</italic>-glucosaminidase,<italic>Pyelonephritis</italic>

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