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      The Effect of Acute Rises in Intraocular Pressure after Intravitreal Bevacizumab Injection on the Peripapillary Retinal Nerve Fiber Layer Thickness and the Role of Anterior Chamber Paracentesis

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          Abstract

          Purpose:

          To evaluate acute changes in intraocular pressure (IOP) and their short-term effects on the peripapillary retinal nerve fiber layer (RNFL) thickness after intravitreal bevacizumab (IVB) injection.

          Methods:

          Fifty-eight eyes of 37 patients with treatment-naïve diabetic macular edema or exudative age-related macular degeneration were included in the study. Patients were divided into two groups, and the participants of each group received 3 monthly injections of IVB. IOP was measured right before the injection, immediately after the injection, and 5 min and 20 min after each injection. Peripapillary, RNFL thickness was measured before the injection and 1 month after the third injection. In the second group, anterior chamber (AC) paracentesis was performed before IVB injection.

          Results:

          IOP values after injection in all sessions were significantly higher in the first group ( P < 0.001). The peripapillary RNFL thickness changes 1 month after the third injection was not statistically significantly different in each group ( P = 0.816 and 0.773 for the first and second groups, respectively).

          Conclusion:

          AC paracentesis is an effective modality to reduce the acute rise in IOP. The effect of acute IOP elevation on the peripapillary RNFL thickness was not statistically significant.

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          Most cited references 21

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          Retinal nerve fiber layer thickness changes in patients with age-related macular degeneration treated with intravitreal ranibizumab.

          To assess the effects of intravitreal ranibizumab therapy on intraocular pressure (IOP) and retinal nerve fiber (RNFL) thickness. Forty-nine eyes of 49 patients with neovascular age-related macular degeneration (AMD) treated with intravitreal ranibizumab injections and 27 fellow eyes not requiring treatment were followed for 1 year. RNFL thickness, as measured by Fourier domain optical coherence tomography, and IOP were determined pre- and postinjection. After 12 months, the mean number of injections received was 4.8 ± 1.6. The incidence of IOP elevations (>5 mm Hg over baseline) observed at the time of injection was 0.4%. Baseline RNFL thickness was 105.7 ± 12.2 μm in the treatment group compared with 101.8 ± 11.6 μm in the control group (P = 0.176). At the end of follow-up, significant RNFL thinning was noted in the treatment group (100.2 ± 11.0 μm, P < 0.001), whereas no differences were found in the control group (100.5 ± 10.8 μm, P = 0.477). Intravitreal ranibizumab injections used to treat AMD caused a significant change in RNFL thickness after 12 months of follow-up.
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            The acute and chronic effects of intravitreal anti-vascular endothelial growth factor injections on intraocular pressure: A review

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              • Record: found
              • Abstract: found
              • Article: not found

              Incidence of damage to the crystalline lens during intravitreal injections.

              To report the incidence of traumatic lens injuries as a complication of intravitreal injection at 5 high-volume academic centers.
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                Author and article information

                Journal
                J Curr Ophthalmol
                J Curr Ophthalmol
                JCO
                Journal of Current Ophthalmology
                Wolters Kluwer - Medknow (India )
                2452-2325
                Jan-Mar 2021
                26 March 2021
                : 33
                : 1
                : 12-16
                Affiliations
                [1 ]Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
                Author notes
                Address for correspondence: Esmaeil Asadi Khameneh, Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. E-mail: asadi_tums@ 123456yahoo.com
                Article
                JCO-33-12
                10.4103/JOCO.JOCO_214_20
                8102946
                34084951
                Copyright: © 2021 Journal of Current Ophthalmology

                This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

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