Quantitative assessment of thyroid-to-background ratio improves the interobserver reliability of technetium-99m sestamibi thyroid scintigraphy for investigation of amiodarone-induced thyrotoxicosis.

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Abstract

Amiodarone-induced thyrotoxicosis (AIT) is caused by excessive hormone synthesis and release (AIT I), a destructive thyroiditis (AIT II), or a combination of both (AIT Ind). Although no gold-standard diagnostic test is available, technetium-99m sestamibi thyroid scintigraphy (99mTc-STS) has been previously reported to be an accurate tool for differentiating subtypes with important therapeutic implications. However, the information to guide reporting of 99mTc-STS is qualitative and highly subjective. This study aims to compare the interobserver reliability of 99mTc-STS before and after the use of quantitative thyroid-to-background ratios (TBRs) displayed on a time-activity curve for differentiation of AIT subtypes.

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Journal

Journal ID (iso-abbrev): Nucl Med Commun

Title: Nuclear medicine communications

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1473-5628

ISSN (Print): 0143-3636

Publication date (Electronic): Apr 2015

Volume: 36

Issue: 4

Affiliations

[1 ] Departments of aNuclear Medicine bEndocrinology cCardiology, Royal Melbourne Hospital, Parkville dCabrini Private Hospital, Malvern, Victoria, Australia.

Article

DOI: 10.1097/MNM.0000000000000260

PubMed ID: 25569865

SO-VID: 32c1cab5-2c72-4810-acc6-e8308d95e556

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