3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Cell adhesion and mechanics as drivers of tissue organization and differentiation: local cues for large scale organization.

      1 , 2
      Current opinion in cell biology
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Biological patterns emerge through specialization of genetically identical cells to take up distinct fates according to their position within the organism. How initial symmetry is broken to give rise to these patterns remains an intriguing open question. Several theories of patterning have been proposed, most prominently Turing's reaction-diffusion model of a slowly diffusing activator and a fast diffusing inhibitor generating periodic patterns. Although these reaction-diffusion systems can generate diverse patterns, it is becoming increasingly evident that cell shape and tension anisotropies, mediated via cell-cell and/or cell-matrix contacts, also facilitate symmetry breaking and subsequent self-organized tissue patterning. This review will highlight recent studies that implicate local changes in adhesion and/or tension as key drivers of cell rearrangements. We will also discuss recent studies on the role of cadherin and integrin adhesive receptors in mediating and responding to local tissue tension asymmetries to coordinate cell fate, position and behavior essential for tissue self-organization and maintenance.

          Related collections

          Author and article information

          Journal
          Curr. Opin. Cell Biol.
          Current opinion in cell biology
          Elsevier BV
          1879-0410
          0955-0674
          Jun 01 2018
          : 54
          Affiliations
          [1 ] Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland; Paul Gerson Unna Group "Skin Homeostasis and Ageing" Max Planck Institute for Biology of Ageing, Cologne, Germany; Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD), Germany. Electronic address: sara.wickstrom@helsinki.fi.
          [2 ] Department of Dermatology, Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. Electronic address: carien.niessen@uni-koeln.de.
          Article
          S0955-0674(17)30110-2
          10.1016/j.ceb.2018.05.003
          29864721
          32c21f07-3564-4c59-ba85-48483d4fe766
          History

          Comments

          Comment on this article