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      Cancer cell extinction through a magnetic fluid hyperthermia treatment produced by superparamagnetic Co–Zn ferrite nanoparticles

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          Abstract

          TEG mediated synthesis of CZF MNPs for cancer cell extinction by using magnetic fluid hyperthermia therapy.

          Abstract

          Cobalt zinc ferrite (CZF) magnetic nanoparticles (MNPs) were synthesized by modifying a thermal decomposition method in the presence of triethylene glycol (TEG). Initially structural, morphological, and magnetic characterizations were carried out in order to confirm their size, polydispersity, colloidal stability, and magnetic property. Fourier transform infrared spectroscopy (FTIR) confirmed the presence of triethylene glycol (TEG) on the surface of CZF MNPs. The CZF MNPs has revealed a superparamagnetic nature with high saturation magnetization, good colloidal stability, high specific absorption rate (SAR), excellent biocompatibility, and a monodispersed nature. All these properties are crucial, for their use as a nanomedicine in magnetic fluid hyperthermia (MFH) treatment; which is considered to be one of the most promising cancer therapies. The prepared CZF MNPs are found to be biocompatible with MCF7 (human breast cancer) and L929 (mouse fibroblast) cell lines, when tested by MTT and SRB assays. Cell particle interaction was examined in depth, by using multiple staining techniques coupled with confocal microscopy. Finally, an in vitro hyperthermia experiment was carried out on MCF7 cells, resulting in the extinction of MCF7 cells by up to 80% within 60 min. The nature of the cell extinction was found and lastly reactive oxygen species (ROS) production was assessed, where ROS is the responsible factor for apoptosis. This research demonstrates that, prepared CZF MNPs can be used as a potential candidate for effective MFH treatment for cancer cell extinction.

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          Most cited references33

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          Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology.

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            Oxidative stress and apoptosis: impact on cancer therapy.

            It is well established that some chemotherapeutic agents and radiation therapy generate reactive oxygen species (ROS) in patients during cancer therapy. Free radicals, particularly ROS have been proposed as common mediators for apoptosis. Recent studies have demonstrated that the mode of cell death depends on the severity of the oxidative damage. This review will address some of the current paradigms of oxidative stress, and antioxidants on apoptosis, and discuss the potential mechanisms by which oxidants can regulate apoptotic pathways. It will also review new developments in eliminating cancer cells by selectively inducing apoptosis. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association.
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              Oxidative stress, DNA methylation and carcinogenesis.

              Transformation of a normal cell to a malignant one requires phenotypic changes often associated with each of the initiation, promotion and progression phases of the carcinogenic process. Genes in each of these phases acquire alterations in their transcriptional activity that are associated either with hypermethylation-induced transcriptional repression (in the case of tumor suppressor genes) or hypomethylation-induced activation (in the case of oncogenes). Growing evidence supports a role of ROS-induced generation of oxidative stress in these epigenetic processes and as such we can hypothesize of potential mode(s) of action by which oxidative stress modulates epigenetic regulation of gene expression. This is of outmost importance given that various components of the epigenetic pathway and primarily aberrant DNA methylation patterns are used as potential biomarkers for cancer diagnosis and prognosis.
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                Author and article information

                Journal
                RSCACL
                RSC Advances
                RSC Adv.
                Royal Society of Chemistry (RSC)
                2046-2069
                2015
                2015
                : 5
                : 58
                : 47225-47234
                Affiliations
                [1 ]Centre for Interdisciplinary Research
                [2 ]D.Y. Patil University
                [3 ]Kolhapur-416006
                [4 ]India
                [5 ]Samsung Biomedical Research Institute
                [6 ]Department of Molecular Cell Biology
                [7 ]Sungkyunkwan University School of Medicine
                [8 ]Suwon 440-746
                [9 ]South Korea
                Article
                10.1039/C5RA04553C
                32e00761-49f3-49a9-9937-37d2fdda7aa6
                © 2015
                History

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