Triiodothyronine and Thyrotropin-Releasing Hormone Interaction on TSH Release in Man

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Abstract

In order to study thyrotropin releasing hormone (TRH)-thyroid hormone interaction, we examined thyrotropin (TSH) behaviour after synthetic TRH administration in 24 euthyroid subjects, 3 patients with primary hypothyroidism and 10 hyper thyroids. 8 normal subjects were studied before and after triiodothyronine (T<sub>3</sub>) treatment with increasíng TRH dosage. Our results suggest that (1) TRH-thyroid hormone interaction is dose-related: this means that TSH response to TRH depends on both thyroid hormone and TRH concentration; (2) T<sub>3</sub>-TRH interaction on TSH release is only roughly quantitative since it is suggested that other extrathyroidal factors interfere with this mechanism controlling TSH secretion.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1972

Publication date (Print): 1972

Publication date (Electronic): 21 November 2008

Volume: 3

Issue: 4

Pages: 250-256

Affiliations

Catania University School of Medicine, Department of Medicine and Division of Endocrinology, Ospedale Garibaldi, Catania

Article

Publisher ID: 178275 Other ID: Hormones 1972;3:250–256

DOI: 10.1159/000178275

PubMed ID: 4631660

SO-VID: 32f330d2-70b9-4b67-8b0f-77c8f10ab6af

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Triiodothyronine and Thyrotropin-Releasing Hormone Interaction on TSH Release in Man

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Karger: Endocrinology

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