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      Triiodothyronine and Thyrotropin-Releasing Hormone Interaction on TSH Release in Man

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          Abstract

          In order to study thyrotropin releasing hormone (TRH)-thyroid hormone interaction, we examined thyrotropin (TSH) behaviour after synthetic TRH administration in 24 euthyroid subjects, 3 patients with primary hypothyroidism and 10 hyper thyroids. 8 normal subjects were studied before and after triiodothyronine (T<sub>3</sub>) treatment with increasíng TRH dosage. Our results suggest that (1) TRH-thyroid hormone interaction is dose-related: this means that TSH response to TRH depends on both thyroid hormone and TRH concentration; (2) T<sub>3</sub>-TRH interaction on TSH release is only roughly quantitative since it is suggested that other extrathyroidal factors interfere with this mechanism controlling TSH secretion.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1972
          1972
          21 November 2008
          : 3
          : 4
          : 250-256
          Affiliations
          Catania University School of Medicine, Department of Medicine and Division of Endocrinology, Ospedale Garibaldi, Catania
          Article
          178275 Hormones 1972;3:250–256
          10.1159/000178275
          4631660
          © 1972 S. Karger AG, Basel

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          Pages: 7
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