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      Cellophane Perinephritic Hypertension in the Dog: Some Biochemical, Hemodynamic and Pathological Characteristics

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          Abstract

          Perinephritic hypertension was induced in mongrel dogs by cellophane encapsulation of one kidney and simultaneous contralateral nephrectomy. Systolic blood pressure began to rise before diastolic blood pressure and both reached maximal values 3 weeks after surgery, their levels becoming stable thereafter up to the end of the study (20 weeks). Cardiac contractility, measured by the index dp/dt/P<sub>40</sub> (rate of rise of isovolumic left intraventricular pressure at a developed left ventricular pressure of 40 mm Hg) was not altered during the evolution of hypertension; heart weight and left ventricular thickness were increased. Plasma renin activity markedly decreased in the chronic phase and plasma urea and creatinine levels rised initially in a moderate but significant way, thereafter remaining stable. The structure of the wrapped kidney remained normal 20 weeks after surgery, when microscopic arterial lesions were seen in other organs. The comparison of the evolution of this hypertensive model with other more commonly used renal experimental hypertension types allows us to conclude that cellophane perinephritic hypertension in the dog must be considered as an individual entity.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1981
          1981
          19 September 2008
          : 18
          : 1-2
          : 67-74
          Affiliations
          Laboratório de Farmacologia and Laboratório de Anatomia Patológica, Faculdade de Medicina, Porto, Portugal
          Article
          158339 Blood Vessels 1981;18:67–74
          10.1159/000158339
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Research Paper

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