+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Cellophane Perinephritic Hypertension in the Dog: Some Biochemical, Hemodynamic and Pathological Characteristics

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Perinephritic hypertension was induced in mongrel dogs by cellophane encapsulation of one kidney and simultaneous contralateral nephrectomy. Systolic blood pressure began to rise before diastolic blood pressure and both reached maximal values 3 weeks after surgery, their levels becoming stable thereafter up to the end of the study (20 weeks). Cardiac contractility, measured by the index dp/dt/P<sub>40</sub> (rate of rise of isovolumic left intraventricular pressure at a developed left ventricular pressure of 40 mm Hg) was not altered during the evolution of hypertension; heart weight and left ventricular thickness were increased. Plasma renin activity markedly decreased in the chronic phase and plasma urea and creatinine levels rised initially in a moderate but significant way, thereafter remaining stable. The structure of the wrapped kidney remained normal 20 weeks after surgery, when microscopic arterial lesions were seen in other organs. The comparison of the evolution of this hypertensive model with other more commonly used renal experimental hypertension types allows us to conclude that cellophane perinephritic hypertension in the dog must be considered as an individual entity.

          Related collections

          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 18
          : 1-2
          : 67-74
          Laboratório de Farmacologia and Laboratório de Anatomia Patológica, Faculdade de Medicina, Porto, Portugal
          158339 Blood Vessels 1981;18:67–74
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Research Paper


          Comment on this article