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      Anti-inflammatory diterpenoids from the root bark of Acanthopanax gracilistylus.

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          Abstract

          Five new ent-pimarane (1-3, 7, and 8) and three new ent-kaurane diterpenoids (4-6) and a new oleanane triterpene acid (9), together with 22 known compounds, were isolated from the root bark of the medicinal herb Acanthopanax gracilistylus. The structures of 1-9 were established based on the interpretation of high-resolution MS and 1D- and 2D-NMR data. The absolute configurations of 7 and 11 were determined by single-crystal X-ray diffraction and electronic circular dichroism analysis. Compounds 7 and 8 represent rare naturally occurring structures based on the devinyl ent-pimarane skeleton. Compounds 3, 10, 14, 16, and 17 exhibited potent inhibitory effects on the release of interleukin-1β (IL-1β), interleukin-8 (IL-8), and tumor necrosis factor (TNF-α) in lipopolysaccharide-stimulated peripheral blood mononuclear cells.

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          Author and article information

          Journal
          J. Nat. Prod.
          Journal of natural products
          1520-6025
          0163-3864
          Nov 26 2014
          : 77
          : 11
          Affiliations
          [1 ] Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for Traditional Chinese Medicine Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, People's Republic of China.
          Article
          10.1021/np500125x
          25338180
          33101f54-7b93-4a5d-9a5d-5b1e497b3a98
          History

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