Predictability of effort, performance, and recreation need by metabolic markers including electrolytes

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Abstract

Abstract. From a group of 12 officer trainees of the Czech Military University in Brno, 100 µL of capillary blood have been collected before and after a 2,400 m run, and after a subsequent recreation period of 30 minutes. The following parameters have been determined: pH, pCO 2 , HCO 3 , BE, blood glucose, ionized K, ionized Mg, and blood pressure. It turned out that those parameters change proportionally, beginning from the situation before the run, throughout the situation after the run and during recreation. Using those proportionalities, a system of predictions of effort and performance was established, whereby the changing of the parameters formed an individual and situation dependent pattern. Thus performance, effort and need for recreation could be estimated individually, before the probands had even moved a limb. 

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Copper and carcinogenesis.

T Theophanides, J Anastassopoulou (2002)

Metal ions play an important role in biological systems, and without their catalytic presence in trace or ultratrace amounts many essential co-factors for many biochemical reactions would not take place. However, they become toxic to cells when their concentrations surpass certain optimal (natural) levels. Copper is an essential metal. Catalytic copper, because of its mobilization and redox activity, is believed to play a central role in the formation of reactive oxygen species (ROS), such as O2-* and *OH radicals, that bind very fast to DNA, and produce damage by breaking the DNA strands or modifying the bases and/or deoxyribose leading to carcinogenesis. The chemistry and biochemistry of copper is briefly accounted together with its involvement in cancer and other diseases.

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Serum ceruloplasmin and copper levels in patients with primary brain tumors.

L Turecký, P Kalina, E Uhlíková … (1984)

Serum copper and ceruloplasmin levels are known to increase in several malignancies such as osteosarcomas, some gastrointestinal tumors, and lung cancer. In this study serum copper and ceruloplasmin levels in 40 patients with primary brain tumors were studied. Both parameters were increased in sera of patients with tumors in comparison with healthy subjects or patients with non-tumorous neurological diseases. It is concluded that copper and ceruloplasmin represent a good complement to some other nonspecific parameters in evaluating the activity of malignancy and the therapeutic results.