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      Out-of-hospital adult cardiac arrests in a university hospital in Central Saudi Arabia

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      Saudi Medical Journal
      Saudi Medical Journal

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          Abstract

          To the Editor I read the article on out-of-hospital cardiac arrests (OHCA) in its entirety and with a great interest.1 Bin Salleeh et al1 original research on OHCA is an outstanding milestone since Conroy and Jolin’s research in late 1990’s.2 The Bin Salleeh et al research should lead to a collaborative nationwide effort among Universities and tertiary level hospitals in publishing data related to OHCA and to address the paucity of OHCA prevalence report in the Middle East.3 McNally4 stated that communities that do not measure their OHCA outcome are not only unable to gauge their performance, but they lack a reference point for quality improvement. Bin Salleeh et al1 study provides a measure to help us appraise and use as reference. What remains is for the region to have a registry. There are many exemplary registry, which galvanized their efforts such as the Pan-Asian Resuscitation outcomes Study (PAROS) in Asia, the European Registry of Cardiac Arrest (EuReCa), and Cardiac Arrest Registry to Improve Survival (CARES) program in USA. In Saudi Arabia, are there any working group panels for OHCA even in an informal basis? And what are the likelihood of establishing a Cardiac Arrest Registry in Saudi Arabia or Middle East in the near future? Or perhaps put it forthright, should the authors lead the way toward a National Cardiac Arrest Registry. There has not been any research related to the role of Emergency Medical Services (EMS) in the region, but your study findings suggested a low, but increased use of EMS. The role of EMS, the quality of their response, and confidence level in EMS lead me to a query related to your finding; how many of the 4 non-traumatic patients who had a return of spontaneous circulation were transported by EMS? Would you be able to assert that patients transported with EMS have a better outcome? Reply from the Author We thank Dr. Alamin Berhanu for his valuable comments regarding our work. He emphasized on the same points we already mentioned in our article. It has been mentioned when we discussed the study limitation “This study was limited to a single university hospital and this limitation could be removed by establishing a national registry of OHCA in Saudi Arabia. Such a registry would allow for national research to identify risk factors, patient characteristics, and trends in Saudi Arabia. In addition, this study supports the continued efforts for public awareness campaigns related to out-of-hospital cardiopulmonary resuscitation (CPR) and attempts to increase survival rates” Regarding his questions: 1) Are there any working group panel for OHCA in Saudi Arabia even in an informal basis? And what are the likelihood of establishing a cardiac registry in Saudi Arabia or Middle East in the near future? Or perhaps put it forthright, should the authors lead the way toward a national cardiac registry. We are not aware if there is an interest or working group panel for OHCA in Saudi Arabia; however, the team involved in this study is interested in the topic and considering the idea of establishing a registry, on the other hand there is gulf registry for acute coronary syndrome not including OHCA in their database. The group has submitted similar work for pediatric age group for publication 2) How many of the 4 non-traumatic patients who had a return of spontaneous circulation in your study were transported by EMS? There are 3 non-traumatic patients were brought by the family member(s), while the other one was brought by a rehabilitation center ambulance, 3) Would you be able to confidently assert that patient transported with EMS have a better outcome. Since all of the 4 patients who had return of spontaneous circulation in our study were not transported by EMS system, it will be difficult to conclude that they would have a better outcome, we need to study larger population from different sites to demonstrate this in our local experience. Hashim Bin Salleeh College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia

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          Out-of-hospital adult cardiac arrests in a university hospital in central Saudi Arabia

          Objectives: To report the characteristics of adult out-of-hospital arrest patients and their outcomes in Riyadh, Saudi Arabia. Methods: This is a prospective descriptive study of out-of-hospital adult arrests incident transported to King Khalid University Hospital, Riyadh, Saudi Arabia between July 2012 and September 2013. Results: A total of 96 adult patients were enrolled in this study. Males represented 62.5% of the participants. The mean age of the study population was 58.9 years, and specifically 30.8 years for traumatic arrests, and 62.9 for non-traumatic. An over-all mortality rate of 95.8% was documented, as well as a low rate of bystander cardiopulmonary resuscitation being performed, and a family member transported most patients to the hospital. Conclusion: A low survival rate for non-traumatic out-of-hospital adult arrest patients and a 100% mortality rate in traumatic arrests were discovered.
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            The importance of cardiac arrest registries

            Sudden cardiac arrest (SCA) is a global health concern. It is estimated that nearly half of all cardiovascular deaths worldwide are due to SCA resulting in an estimated 4 to 6 million cases each year [1,2]. Several countries have developed national out-of-hospital cardiac arrest (OHCA) registries for surveillance and quality improvement purposes including: Japan, Denmark, Singapore, Korea, Sweden, Ireland and many others are beginning to collect data. There are also collective efforts in Asia (PAROS), Europe (EuReCa), and the United States (CARES) underway [3-5]. Collecting data is an essential first step in determining the subsequent steps needed to strengthen the chain-of-survival within a community. It follows the business mantra that “it is hard to manage something if you don’t measure it”. Communities that don’t measure their OHCA outcomes are not only unable to gauge their performance but also lack a reference point to determine the impact of any implemented quality improvement efforts. In 2010, the American Heart Association recognized the importance of data collection for OHCA and identified the essential elements of a high quality resuscitation system that includes: measurement, benchmarking and providing feedback to influence change [6]. Registries PAROS The Pan-Asian Resuscitation Outcomes Study (PAROS) network was established in 2009 as an international, multicenter, prospective registry of OHCA events across the Asia-Pacific. The goal of the network “is to provide benchmarking against established registries and to generate best practice protocols for Asian emergency medical services (EMS) systems, to impact community awareness of pre-hospital emergency care, and ultimately to improve OHCA survival” [3]. To date the registry includes a population base of over 89 million with 9 countries being represented. EuReCa In 2008, the European Resuscitation Council set up a working group with the goal of developing a common European Registry of Cardiac Arrest (EuReCa) and to be considered for use as a central tool for quality management in resuscitation. A pilot was performed and it was felt that it might best benefit those countries and regions that had not already set up registries of their own [4]. CARES In 2004, the US Center for Disease Control and Prevention developed the Cardiac Arrest Registry to Improve Survival (CARES) program https://mycares.net with the Department of Emergency Medicine at the Emory University School of Medicine. The registry evaluates OHCA of non-traumatic etiology for patients that receive resuscitative efforts, including CPR and/or defibrillation. Participating sites include data from three sources that allow for a patient centric outcome to be measured by linking data from: EMS providers, dispatch centers and hospitals. In the US the majority of persons who experience an OHCA do not receive bystander-assisted CPR or other time sensitive interventions that have been proven to increase survival rates (e.g. defibrillation). CARES was developed as a low cost, high impact public health surveillance system to help identify opportunities for improvement in OHCA care. It was designed from the onset to make the process of data collection as simple and easy as possible. Because CARES data are collected in a uniform manner, the system enables benchmarking and continuous quality improvement in communities of any size. Nearly half of OHCA events are witnessed, so efforts to improve survival should consider the timely and effective delivery of interventions by bystanders and emergency providers [5]. Global data trends and effectiveness A recent data published from the Danish registry suggests an improvement in survival over time with a corresponding increase in both bystander CPR and defibrillation use [7]. The All Japan Utstein Registry has also previously shown an increased survival trend over time and an analysis currently under review for CARES data suggests the same as well [8]. These improved survival trends are most likely multifactorial in nature and since they are based on observational data it is impossible to pinpoint with certainty what is responsible for these trends. An improved survival trend over time is important to acknowledge but equally important is understanding the limitations of registry data. Efficacy is the extent to which a treatment has the ability to bring about its intended effect under ideal circumstances, such as in a randomized clinical trial. Effectiveness is the extent to which a treatment achieves its intended effect in the usual clinical setting. Efficacy is not the same as effectiveness. A treatment is effective if it works in real life in non-ideal circumstances. Effectiveness cannot be measured in controlled trials, because the act of inclusion into a study is a distortion of usual practice. Just as a randomized control trial can’t be used to answer an effectiveness question an observational study can’t be used to answer an efficacy question. It is important to understand that both study designs are needed to help advance our understanding of OHCA as neither alone can answer both treatment and performance questions. This dual requirement is highlighted below. “It is an irony that drugs are licensed for use almost exclusively on the results of controlled trials, yet they are withdrawn from use because of observational data that would not be acceptable to licensing authorities” [9]. In an editorial on the limitations of clinical trials in cardiac arrest, author Arthur Sanders acknowledged that “there are fundamental tensions between the principles of randomized trial design and the practice of resuscitation that make the conduct of any clinical trial of out-of hospital cardiac arrest challenging”. He added that “Randomized, controlled trials may not be the best strategy for making progress in the management of a public health problem” and considered that an alternative strategy would be to use a continuous-quality-improvement model.” He further concluded that “there are inherent limitations in even a well-designed, carefully executed clinical trial in advancing resuscitation science. It is therefore important that we reassess the role of clinical trials and alternative strategies in improving the rate of survival from cardiac arrest. The goal of resuscitation is saving lives; research helps achieve this goal but is not the goal itself” [10]. The future OHCA registries will continue to play an important role in the future at both the community and country level. Benefits will include: determining clinical outcomes; uniform benchmarking; identifying opportunities for improvement and tracking the diffusion of new therapies; and promoting accountability and answering effectiveness research questions. Additional supplemental data elements could also be considered to enhance registries to: track AED locations in communities in real time to help a dispatcher link a caller with a nearby device; include CPR quality metrics in an effort to improve clinical performance by focusing on compliance with recommended guidelines; including telephone CPR data and quality improvement tools to ensure dispatchers recognize OHCA over the phone while minimizing the time from call receipt to instructions being provided and eventual first compression being performed. More robust hospital data could also be considered where resources allow to improve timely reperfusion and hypothermia treatment for OHCA patients when indicated. OHCA data should be used as a starting point for improving a community based system of care by participating in a registry and quality improvement program but saving a life should continue to be the goal not proving how you did it.
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              Cardiac arrest in Saudi Arabia: a 7-year experience in Riyadh.

              All out-of-hospital and Emergency Department (ED) cardiac arrests treated at a tertiary care hospital in Riyadh, Saudi Arabia, from 1989 through 1995 were studied. Of patients arresting out-of-hospital, 3.0% received bystander cardiopulmonary resuscitation (CPR), 9.1% had some prehospital CPR, 12.1% were transported via ambulance, and 13.6% had ventricular fibrillation (VF) on ED arrival. In the witnessed arrests (80%), the estimated interval from arrest to initiation of CPR was 21.1 +/- 14.7 min. None of these variables was shown to influence outcome. Survival to hospital discharge from out-of-hospital arrest was 5.1% for adults and 7.4% for children; all had poor neurologic outcome. For patients arresting in the ED, an initial rhythm of ventricular tachycardia (VT) or VF was strongly correlated with survival. Survival from ED arrest was 30.4% in adults, 42.9% in children; all but one had normal neurologic outcome. These results are similar to those reported from large cities and EDs elsewhere. The unique set of variables influencing out-of-hospital care and transportation in Riyadh are discussed, and potential areas for improvement are noted.
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                Author and article information

                Journal
                Saudi Med J
                Saudi Med J
                SaudiMedJ
                Saudi Medical Journal
                Saudi Medical Journal (Saudi Arabia )
                0379-5284
                December 2015
                : 36
                : 12
                : 1500
                Affiliations
                [1] Research & Clinical Support, Family Practice Clinic, Toronto, Ontario, Canada
                Article
                SaudiMedJ-36-1500
                10.15537/smj.2015.12.13689
                4707411
                26620997
                3320b135-0946-4b27-bae5-dbd0e9eebe1a
                Copyright: © Saudi Medical Journal

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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